Tag Archive for: Pesticide series

The Science Shows Glyphosate must be Banned

The Scientific Evidence Justifies Banning Glyphosate

The primary scientific study pesticide regulators worldwide used to justify the approval of Glyphosate, the active ingredient in Roundup and many other herbicides, has been retracted due to fraud.

This study, by Gary Williams, Robert Kroes, and Ian Munro, was used to cast doubt on the numerous published studies showing that Glyphosate caused cancers and many other diseases.

Researchers Alexander A. Kauro and Naomi Oreskes published a study in Environmental Science and Policy that identified multiple flaws in the Williams paper, including the fact that it was ghostwritten by Monsanto employees, which constitutes academic fraud. The Williams paper used unpublished studies from Monsanto and ignored a large number of scientific studies showing the multiple diseases Glyphosate causes, including cancer.

This paper was cited and used by regulators as the basis for approving the use of glyphosate-based pesticides and overriding the evidence presented in hundreds of studies showing the immense harm caused by them to human health and the environment.

This retraction comes a few months after the landmark study on glyphosate by Panzacchi et al. was published on June 10, 2025, examining total lifetime exposure to the so-called ‘safe’ levels to which most people are subjected [2].

The study found that the lowest dose of 0.5 mg/kg, which is four times lower than the US Environmental Protection Agency’s (EPA) proposed ‘safe’ level, caused increased rates of both benign and malignant tumors in various parts of the body compared to the controls. These tumors included leukemia, skin, liver, thyroid, nervous system, ovary, mammary gland, adrenal glands, kidney, urinary bladder, bone, endocrine system, pancreas, uterus, and spleen. [2,3]

Now that William’s study has been retracted, the main reason for trusting the safety of glyphosate-based herbicides has disappeared, leaving no reason to avoid banning these highly toxic poisons that pollute nearly every part of the environment and the bodies of most living creatures, especially us and our children

There are an enormous number of published scientific studies showing that glyphosate-based pesticides are responsible for multiple serious health problems for people, animals, and the wider environment.

The widespread adoption of GMO crops in the U.S. has resulted in a massive increase in the application of glyphosate, the active ingredient in Roundup, as the primary method of weed control. [4]

The Panzacchi study confirms evidence from earlier research, including that by the IARC and Seralini et al., among many others[5,6]. It also validates the accuracy of “Genetically engineered crops, glyphosate and the deterioration of health in the United States of America,” where Dr. Nancy Swanson, our co-authors, and I demonstrated how glyphosate and GMOs are linked to over 20 chronic diseases in the U.S [4].

The First Credible Peer-reviewed Lifetime Study of GMOs and Roundup

Until Panzacchi et al. was published, there was only one credible, independent, non-industry funded, peer-reviewed lifetime feeding study of GMOs and Roundup. It found that mammary and other tumors, liver and kidney damage result from regular exposure to minute amounts of Roundup and/or a diet containing GMO corn, similar to the typical exposures people get from food. [6]

The image above shows a rat with large mammary tumors caused by consuming glyphosate at the usual levels found in food. The tumors on the right-hand side, starting from the top, are caused by eating GMO corn, GMO corn treated with Roundup, or just Roundup. (Seralini et al.)  

All female rats in the study that were fed GMOs and/or Roundup (Treated Group) developed mammary tumors and died earlier than the rats fed non-GMO food without Roundup (Control Group), except for one rat that died early from an ovarian tumor. This finding aligns with Thongprakaisang et al., showing that glyphosate promotes the growth of human breast cancer cells via estrogen receptors. [7]

 Treated males presented four times the number of tumors that were large enough to be felt by hand than the controls, and these occurred up to six hundred days earlier.

The International Agency for Research on Cancer (IARC)

The International Agency for Research on Cancer (IARC) has assigned glyphosate a Group 2A rating for Cancer, the second-highest classification. [5]

This means it causes cancer in animals and has some evidence of causing cancer in humans, most notably non-Hodgkin lymphoma.

A study by Flower et al. examined the levels of cancer in children whose parents used glyphosate for weed control. They found that these children had increased levels of all childhood cancers, including all lymphomas, such as non-Hodgkin lymphoma.[8]

A case-controlled study by Swedish scientists Lennart Hardell and Mikael Eriksson also linked non-Hodgkin lymphoma to exposure to various pesticides and herbicides, including glyphosate. [9] The link between glyphosate and non-Hodgkin lymphoma has resulted in significant court cases, most of which Bayer-Monsanto has lost and awarded millions of dollars to the victims.

Genetically engineered crops, glyphosate, and the deterioration of health in the United States of America

Dr. Nancy Swanson and I, along with our co-authors Jon Abrahamson and Bradley Wallet, published a peer-reviewed paper, “Genetically engineered crops, glyphosate, and the deterioration of health in the United States of America,” showing how glyphosate and GMOs are linked to over 20 diseases in the U.S. The study searched US government databases for genetically engineered crop data, glyphosate application data, and disease epidemiological data. This was correlated with numerous diseases linked to the increased use of glyphosate and GMOs. A standard accepted statistical analysis showed that the odds of glyphosate and GMOs not being the cause of these diseases was 10,000 to 1. On top of these, numerous studies are confirming the link between GMOs and glyphosate with these diseases. [4]

We compiled this data into graphs demonstrating the rise in diseases, glyphosate, and GMOs. We also included green trend lines to illustrate that these increases are linked to the growing use of genetically engineered (GE) corn and soy, along with glyphosate.

Correlations with Cancer

We found strong correlations for cancers of the liver, kidney, thyroid, and pancreas, as well as deaths from acute myeloid leukemia. These correlations have now been confirmed by Panzacchi et al., who demonstrated that small levels of glyphosate and glyphosate herbicides cause these issues in rats.

Thyroid cancer, in particular, appears to be linked to the introduction of GE crops and the use of glyphosate. It seems to affect women more, while men are more susceptible to liver and kidney cancers.

Conclusion

Research shows glyphosate-based herbicides cause multiple serious chronic diseases. Over 50 years of regulation since glyphosate’s introduction in 1974 clearly highlight regulatory failure. Authorities should fulfill their duty to protect the public by banning these substances.

References             

  1. Alexander A. Kaurov and Naomi Oreskes, The afterlife of a ghost-written paper: How corporate authorship shaped two decades of glyphosate safety discourse, Environmental Science and Policy 171 (2025) 104160
  2. Panzacchi, S., Tibaldi, E., De Angelis, L. et al. Carcinogenic effects of long-term exposure from prenatal life to glyphosate and glyphosate-based herbicides in Sprague–Dawley rats. Environ Health 24, 36 (2025). https://doi.org/10.1186/s12940-025-01187-2
  3. EPA R.E.D. FACTS Glyphosate, https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_PC-417300_1-Sep-93.pdf
  4. Nancy L. Swanson, Andre Leu, Jon Abrahamson, and Bradley Wallet, Genetically engineered crops, glyphosate and the deterioration of health in the United States of America, Journal of Organic Systems, 9(2), 2014
  5. “Glyphosate,” IARC Monographs–112, http://monographs.iarc.fr/ENG/Monographs/\vol112/mono112-02.pdf.
  6. Gilles-Éric Séralini et al., “Long-Term Toxicity of a Roundup Herbicide and a Roundup-Tolerant Genetically Modified Maize, Environmental Sciences Europe, republished study (2014): 14.
  7. Thongprakaisang, S., Thiantanawat, A., Rangkadilok, N., Suriyo, T. and Satayavivad, J., 2013, Glyphosate induces human breast cancer cells growth via estrogen receptors, Food and Chemical Toxicology, 59: 129-136.
  8. K. B. Flower, J. A. Hoppin, C. F. Lynch, A. Blair, C. Knott, D. L. Shore, et al., “Cancer Risk and Parental Pesticide Application in Children of Agricultural Health Study Participants,” Environmental Health Perspectives 112, no. 5 (2004): 631–35.
  9. Lennart Hardell and Mikael Eriksson, “A Case-Control Study of Non-Hodgkin Lymphoma and Exposure to Pesticides,” Cancer 85, no. 6 (March 15, 1999): 1353–60.

Pesticides in Food Cause Brain Damage in Children

More Evidence of Harm

Two recent studies reveal that even tiny amounts of chlorpyrifos, a common pesticide that leaves residues on produce, can cause brain damage in unborn and developing children. This exposure occurs from consuming fresh fruits and vegetables that have been treated with this toxic insecticide.

The latest review into Autism has ignored the effects of pesticides in the development of this and related diseases. Exposure to small amounts of pesticides in food can harm the brain’s normal development, leading to a range of serious issues observed in children, including autism spectrum disorder, bipolar disorder, ADHD, and other developmental and behavioral challenges.

Brain Damage and IQ Reductions in Children

The two most recent studies clearly show brain damage in children.

A cohort study of 270 youths aged 6 to 14 years found that progressively higher prenatal exposure to chlorpyrifos (CPF) was significantly associated with progressively greater alterations in brain structure, function, and metabolism, as well as progressively poorer measures of motor speed and motor programming.

The study showed that prenatal CPF exposure is connected to long-term changes in brain development and behavior. The MRI brain scan images above clearly show damage in the yellow and red areas. [1]

The second study looked at the effects on offspring exposed to chlorpyrifos through their pregnant mothers. The researchers found that it causes long-lasting changes in sleep-related breathing patterns and inflammation in the hippocampus. They stated, “The results support the hypothesis that adult sleep and brain inflammation phenotypes may be modulated by early-life chemical exposures during pregnancy and lactation.” [2]

Studies conducted independently by researchers at Columbia University’s Center for Children’s Environmental Health, the University of California, Berkeley, and the Mount Sinai School of Medicine found that fetal exposure to small amounts of organophosphate pesticides caused a range of brain abnormalities, leading to children with reduced IQs, diminished attention spans, and increased vulnerability to ADHD [3,4,5].

The study by Rauh et al., published in the Proceedings of the National Academy of Sciences of the United States of America, confirmed previous findings. The researchers used MRI scans that showed a wide range of visible brain abnormalities in children exposed to CPF in utero through standard, nonoccupational means [6]. These can be clearly seen in the image below.

Autism

Autism has reached epidemic levels in the U.S. The chart below clearly shows the link between the sharp rise in glyphosate use, mainly due to the widespread adoption of GMOs since the 1990s, and the increase in these diseases.

Researchers have demonstrated how small exposures to glyphosate harm normal nerve development.

The image above illustrates how glyphosate damages nerve development. The cells exposed to glyphosate had shorter, unbranched axons (the long ‘arms’ of the nerve) and less complex dendritic arbors (the smaller ‘fingers’ extending from the cell body). It is clear from the image that the glyphosate-exposed cells do not develop properly and, therefore, cannot function effectively. [8]

Scientists have identified how glyphosate affects nerve development and confirmed that these effects cannot be reversed. The main concern is that the brain, the largest nerve network in the human body, continues developing in the unborn, newborn, and growing children. Even small amounts of glyphosate in food can harm normal brain development, leading to significant issues such as autism spectrum disorder, bipolar disorder, ADHD, and other developmental and behavioral problems.

The Special Needs of Children, the Developing Fetus, and Newborns

Many scientific researchers have voiced concerns that current methods for testing pesticides and toxins, including vaccines, are severely inadequate for children. The U.S. President’s Cancer Panel (USPCP) report, written by leading scientists and medical experts from the U.S. Department of Health and Human Services, the National Institutes of Health, and the National Cancer Institute, stated, “They (children) are at special risk due to their smaller body mass and rapid physical development, both of which magnify their vulnerability to known or suspected carcinogens, including radiation.” [9]

This is a critical issue because extensive research shows that both the fetus and the newborn are constantly exposed to various chemicals, including pesticides, plasticizers, heavy metals like mercury, neurotoxins such as aluminum and fluoride, and endocrine disruptors.

The USPCP stated, “Some of these chemicals are found in maternal blood, placental tissue, and breast milk samples from pregnant women and mothers who recently gave birth. These findings indicate that chemical contaminants are being passed on to the next generation, both prenatally and during breastfeeding. Numerous environmental contaminants can cross the placental barrier; to a disturbing extent, babies are born ‘pre-polluted.’ Children also can be harmed by genetic or other damage resulting from environmental exposures sustained by the mother (and in some cases, the father). There is a critical lack of knowledge and appreciation of environmental threats to children’s health and a severe shortage of researchers and clinicians trained in children’s environmental health” [9].

The information from USCP clearly shows that current regulatory systems have failed to protect unborn and developing children from exposure to many toxic pesticides and other chemicals. This failure has serious consequences, especially with the increase of various major health problems in children and later as adults.

Developmental Neurotoxicity

Scientific research shows that many pesticides affect the development of the nervous system in fetuses and children. Several pesticides, such as organophosphates, carbamates, pyrethroids, and neonicotinoids, cause serious harm because they are designed to target nervous systems. This is known as a neurotoxin—or, in simple terms, a nerve poison.

The brain is the largest group of nerve cells, and many scientific studies show that when a fetus and newborn are exposed to small amounts of these pesticides—below the current ‘safe’ limits set by regulatory authorities—they can significantly impact brain function. [10]

A major consequence is developmental neurotoxicity, where the poison harms the developing nervous system. This harm disrupts the normal growth of the brain and other parts of the nervous system, such as the auditory nerves, optic nerves, and autonomic nervous system, resulting in lower IQs, ADHD, autism spectrum disorders, poor physical coordination, anger management issues, bipolar/schizophrenia spectrum disorders, depression, and problems with eyesight and hearing.

The brain damage shown in the images above resulted from mothers consuming fresh fruits, vegetables, and cereals commonly found in the North American diet, which contains regulated ‘safe’ pesticide residues like chlorpyrifos and glyphosate. This shows that exposure to chemicals at levels well below current permissible residues can harm a fetus and breastfeeding infants, even if the mother does not experience any adverse effects from the exposure.

Pesticide and Chemical Residues in Food are not Safe

Eating food with pesticide and chemical residues can harm young children because their nervous systems are still developing.

Some of the most concerning studies indicate that pesticide damage can be passed down to future generations. Not only are offspring born with damage to the nervous system, reproductive system, and other organs, but great-grandchildren can also be affected as well [11, 12, 13].

Researchers in a 2012 study discovered that pregnant rats and mice exposed to the fungicide vinclozolin during fetal reproductive development showed significant increases in spermatogenic cell defects, testicular abnormalities, prostate abnormalities, kidney abnormalities, and polycystic ovarian disease in future generations.

Another study showed that when pregnant rats were exposed to a combination of permethrin, a common insecticide, and DEET (N,N-diethyl-meta-toluamide), the most common insect repellent, there was an increase in pubertal abnormalities, testis disease, and ovarian disease (including primordial follicle loss and polycystic ovarian disease) in future generations.

The studies above show that small exposures to pesticides and toxic chemicals—such as adjuvants and preservatives in vaccines—during critical periods of fetal development can cause various diseases that might be passed down to future generations. This implies that pregnant women consuming food with trace amounts of pesticides and biologically active chemicals—like food dyes, preservatives, and other synthetic additives—may unintentionally expose their children, grandchildren, and great-grandchildren to irreversible damage to their reproductive systems and other organs.

Exposure to pesticides and neurotoxins is one of the worst forms of child abuse

What kind of cruel society poisons its children instead of giving them the best start in life? [14]

As a society we need to assure parents can safeguard their children by providing a nutritious, organic, whole food diet and avoiding exposure to synthetic toxins. Many studies demonstrate the benefits of an organic diet, especially in reducing pesticide levels in children’s bodies. I have published an article on our website https://regenerationinternational.org/2025/07/10/organic-food-protecting-our-children/ that explains why organic foods are the best choice for our health and our children’s health.

Buying organic whole foods instead of highly processed ones is more affordable. It offers better value because it contains more essential nutrients, including vitamins, minerals, amino acids, and antioxidants, that are crucial for health. Highly processed foods are mostly refined carbohydrates and sugar that lack essential nutrients and are packed with toxic preservatives, colorings, surfactants, plasticizers, pesticides, and other harmful chemicals.

Switching to a diet of organic whole foods not only saves money, but also ensures a healthier future for our families.

References

  1. Bradley S. Peterson, Sahar Delavari, Ravi Bansal, Siddhant Sawardekar, Chaitanya Gupte, Howard Andrews, Lori A.Hoepner, Wanda Garcia,Frederica Perera, and Virginia Rauh, (2025) Brain Abnormalities in Children Exposed Prenatally to the Pesticide Chlorpyrifos, JAMA Neurology, Published online August 18, 2025.
  2. Miglioranza E, Rullo L, Alvente S, Bastianini S, Coraci D, Lo Martire V, et al. (2025) Long lasting effects of perinatal exposure to the Chlorpyrifos pesticide on sleep, breathing, and neuroinflammation in adult mice. PLoS One 20(8): e0328581. https://doi.org/10.1371/journal.pone.0328581
  3. Rauh, Virginia, Srikesh Arunajadai, Megan Horton, Frederica Perera, Lori Hoepner, Dana B. Barr, and Robin Whyatt. “7-year neurodevelopmental scores and prenatal exposure to chlorpyrifos, a common agricultural insecticide.” Environmental Health Perspectives, 119 (2011): 1196–1201. Published online April 21, 2011.
  4. Pastor, Patricia N. and Cynthia A. Reuben, “Diagnosed attention deficit hyperactivity disorder and learning disability: United States, 2004–2006.” National Center for Health Statistics, Vital and Health Statistics, 10, no. 237 (July 2008): 1–14.
  1. Engel, Stephanie M., James Wetmur, Jia Chen, Chenbo Zhu, Dana Boyd Barr, Richard L. Canfield, and Mary S. Wolff. “Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in children.” Environmental Health Perspectives 119 (2011): 1182–1188. Published online April 21, 2011, http://ehp.niehs.nih.gov/1003183/
  1. Rauh, Virginia, Frederica P. Perera, Megan K. Horton, Robin M. Whyatt, Ravi Bansal, Xuejun Hao, Jun Liu, Dana Boyd Barr, Theodore A. Slotkin, and Bradley S. Peterson. “Brain anomalies in children exposed prenatally to a common organophosphate pesticide.” Proceedings of the National Academy of Sciences of the United States of America 109, no. 20 (May 2012): 7871–7876.
  2. Nancy L. Swanson, Andre Leu, Jon Abrahamson, and Bradley Wallet, Genetically engineered crops, glyphosate and the deterioration of health in the United States of America, Journal of Organic Systems, 9(2), 2014
  3. Romina P. Coullery, María E. Ferrari, Silvana B. Rosso, Neuronal development and axon growth are altered by glyphosate through a WNT non-canonical signaling pathway, NeuroToxicology 52 (2016) 150–161
  4. “U.S. President’s Cancer Panel 2008–2009 Annual Report; Reducing Environmental Cancer Risk: What We Can Do Now.” Suzanne H. Reuben for the President’s Cancer Panel, U.S. Department Of Health And Human Services, National Institutes of Health, National Cancer Institute, April 2010.
  1. Qiao, Dan, Frederic Seidler, and Theodore Slotkin. “Developmental neurotoxicity of chlorpyrifos modeled in vitro: Comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells.” Environmental Health Perspectives 109, no. 9 (September 2001): 909–913.
  2. Manikkam, Mohan, Carlos Guerrero-Bosagna, Rebecca Tracey, Md. M. Haque, and Michael K. Skinner. “Transgenerational actions of environmental compounds on reproductive disease and identification of epigenetic biomarkers of ancestral exposures.” PLoS ONE 7, no. 2 (February 2012): e31901.
  1. Manikkam, Mohan, Rebecca Tracey, Carlos Guerrero-Bosagna, and Michael K. Skinner. “Pesticide and insect repellent mixture permethrin and DEET induces epigenetic transgenerational inheritance of disease and sperm epimutations.” Journal of Reproductive Toxicology 34, no. 4 (December 2012): 708–719.
  1. Guerrero-Bosagna, Carlos, Trevor R. Covert, Matthew Settles, Matthew D. Anway, and Michael K. Skinner. “Epigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers.” Reproductive Toxicology 34, no. 4 (December 2012): 694–707.
  1. Leu, Andre. Poisoning Our Children: The Parents’ Guide to the Myths of Safe Pesticides. Acres U.S.A. Greely, Colorado, USA 2018, ISBN 978-1-601-73140-1.

There Is No Need to Poison Our Food – Higher Yields in Regenerative and Organic Agriculture Based on the Science of Agroecology

Introduction

Toxic synthetic pesticides and soluble chemical fertilizers are damaging our health and harming the environment. They significantly contribute to the rise of chronic diseases, the decline of insects, birds, and other species, as well as widespread pollution, algae blooms in our streams and rivers, and dead zones in the oceans. This is justified on the notion that without poisoning our food and environment, we would starve.

This is a mythology created through ongoing misinformation campaigns by the poison cartels, their captive media, researchers, academics, and regulators. This article clearly shows that we can produce more food that is healthier without these toxic, degenerative inputs.

Regeneration International is an international network of more than 680 partner organizations in 80 countries in Africa, Asia, Latin America, Oceania, North America, and Europe. Our Mission:

To promote, facilitate, and accelerate the global transition to regenerative food, farming, and land management for the purpose of restoring climate stability, ending world hunger, and rebuilding deteriorated social, ecological, and economic systems.

We use the term “Regenerative and Organic agriculture based on the science of Agroecology” to describe nature-based farming systems, distinguishing them from degenerative industrial agriculture.

These systems adopt practices like longer rotations, cover crops, green manures, legumes, compost, and organic fertilizers to increase Soil Organic Matter (SOM). These methods include organic farming, biodynamics, natural farming, agroforestry, agroecology, permaculture, holistic managed grazing, silvopasture, syntropic farming, SRI (the system of rice intensification), and many other agricultural approaches that can enhance SOM levels. SOM is a key indicator of soil health because soils with low SOM are considered unhealthy and tend to produce poor crops.

Yields

The Rodale Institute’s 40-Year-Report on their Farming Systems Trial should end the myth that we need to poison our food, bodies, and environment with toxic pesticides, synthetic fertilizers, and GMOs to feed the world. Rodale’s scientific trials clearly show that these degenerative systems are inferior to Regenerative Organic Agriculture on every key criterion. (Rodale 2022)

The Farming Systems Trial demonstrated that organic manure systems using either standard or limited tillage had higher levels of SOM and greater crop yields compared to GMO herbicide no-till and standard industrial farming systems. The trials achieved the highest maize yields in the tilled organic manure system, with the greatest increases in SOM occurring where the organic manure system used limited tillage. The limited tillage field was tilled every second year. Importantly, 40 years of research show that organic maize yields have been 31 percent higher than those of industrial farming systems during drought years.

Rice Production

The following section demonstrates that rice production and profitability can increase through regenerative and organic agriculture, rooted in the science of agroecology.

A research project conducted in the Philippines by MASIPAG found that the yields of organic rice were similar to those of industrial systems. Very significantly, the research project compared the income of similarly sized industrial and organic farms and found that the average income for organic farms was 23,599 Pesos, compared to 15,643 Pesos for the industrial farms (Bachman et al. 2009).

Improved Organic Productivity: Mean yield of rice, 2007 (kg/ha), n=840

Masipag Organic Masipag Conversion Chemical Farming
Luzon 3,743 3,436 3,851
Visayas 2,683 2,470 2,626
Mindanao 3,767 3,864 4,131
Maximum 8,710 10,400 8,070

Improved income from organic farm: Net agricultural income per hectare, 2007 (Pesos)

Masipag Organic Masipag Conversion Chemical Farming
Luzon 24,412 18,991 13,403
Visayas 22,868 16,039 13,738
Mindanao 23,715 17,362 19,588
Average 23,599 17,457 15,643

Improved income from organic farm: Annual Balance of Income and Expenditure per Household, 2007 (in Pesos), n=840

Masipag Organic Masipag Conversion Chemical Farming
Luzon 11,331 9,702 -1,266
Visayas -1,090 287 -4,974
Mindanao 5,481 -232 -7,546
Mean Average 5,967 3,407 -4,546

While the rice yields are similar, the most significant information that came from this study was when the normal family living expenses were deducted from the net income. It showed that at the end of the year, on average, the organic rice farmers have a surplus income of 5,967 pesos, whereas the industrial rice farmers had a loss of 4,546 pesos.

System of Rice Intensification (SRI)

The advancements in the science and practices of the System of Rice Intensification are yielding impressive results that surpass the average yields for chemical paddy rice. Professor Norman Uphoff of Cornell University, one of the world’s leading experts in SRI methods, provides multiple examples of high yields:

Crop Productivity Increases

The combined changes in crop management result in plant phenotypes that produce greater crop yields and exhibit more resilience to stresses. Rice yields are improved by 20-50%, and often by more (Uphoff 2012). Better grain quality often commands a higher market price, and when the rice is organically grown, its price can be even higher.

Professor Uphoff states, “However, in the 2011 kharif season in the Indian state of Bihar, five first-time SRI farmers in one village (using hybrid varieties) matched or exceeded the previous world-record yield for paddy of 19 tons/ha. According to Bihar Department of Agriculture data, one achieved a yield of 22.4 tons/ha, almost ten times the average paddy yield for the state. The dry weight was an unprecedented 20.16 tons/ha [48]. These measurements, made with standard methods and with hundreds of observers looking on, have been officially accepted.”

Professor Uphoff further states:“SRI methods have often enabled poor farmers to double, triple or even quadruple their yields, not just individually but on a village level, without having to purchase new varieties or agrochemical inputs [49–52]. Such resource-limited farmers started at very low levels of production, it is true. But for them, to go from 1 ton per hectare to 4 tons, or from 2 tons to 8 tons, without added costs of production, makes a huge difference in their food security and well-being. For the 2011 kharif season, the Bihar Department of Agriculture in India has calculated an average SRI yield of 8.08 tons/ha on 335,000 hectares across all 38 districts of the state. This was more than three times the state-wide average of 2.5 tons/ha.”

SRI produces roughly twice the yields with organic fertilizers compared to chemical fertilizers, averaging 7 tons per hectare versus 3.5 tons per hectare.

Professor Uphoff provides the following examples of the multiple benefits that come from SRI

Increased Income

Whether the production costs and labor requirements for SRI methods are higher, equal to, or lower than those in industrial rice production will depend on current practices, the degree of intensification, and the types of changes needed to implement SRI practices (Thakur et al. 2013). Significantly higher yields increase both labor and input factor productivity with SRI,

boosting farmers’ income from rice in most cases by 50% or more with SRI adoption across all three of the scenarios noted above (Thakur et al. 2013; Kathikeyan et al. 2010; Uphoff 2016).

Reduced water requirements and greater drought resistance:

SRI plants thrive with 30-50% less irrigation water compared to continuously flooded rice. Reduced competition among plants, combined with aerated and organic matter-enriched soils, promotes healthier plants both above and below ground. These plants develop larger, deeper, and less-senescing root systems that are better equipped to withstand drought and extreme temperatures. Additionally, organic matter-enriched soils can retain more water and nutrients (Jagannath et al. 2013; Zheng et al. 2013; Barison and Uphoff 2011; Sridevi and Chellamuthu 2012; Chapagain et al. 2011; FAO 2005).

Higher pest and disease resistance:

Stronger and healthier rice plants are less susceptible to pests and diseases. Due to the much lower plant density in SRI, less humidity accumulates within the plant canopy, allowing air to circulate more freely among the plants. This creates a less favorable environment for pests and diseases compared to densely-planted and continuously-flooded industrial rice paddies (Karthikeyan et al. 2010; Kumar et al. 2007; Visalakshmi et al. 2014).


Caption to picture above: Resistance to biotic and abiotic stresses based on alternative crop management: two adjacent rice paddy fields in Crawuk village, Ngawi district, East Java, Indonesia, after both were impacted by a brown planthopper (BPH) attack followed by a tropical storm in June 2011. The paddy field on the left, planted with an improved rice variety (Ciherang) and utilizing inorganic fertilizer and agrochemical protection, produced almost no yield due to BPH burn and lodging. In contrast, the field on the right, 1,000 m2 in area, planted with an aromatic unimproved variety (Sinantur) and employing organic SRI management, yielded 800 kg, or 8 tons/ha. This picture was provided to the author by Ms. Miyatty Jannah, the farmer who managed the field on the right. Source: (Uphoff 2012)

 

Greater resistance to rain and wind damage from storms.

As SRI plants exhibit thicker tillers and deeper roots, and are spaced more widely, they have been shown to withstand strong rains and winds better than industrial paddy rice. A study in Japan reported that during a storm event, 10% of SRI fields lodged compared to 55% of an adjacent industrially managed field (Chapagain et al. 2011).

SRI Mitigates Greenhouse Gas Emissions

SRI management contributes to mitigation objectives by reducing greenhouse gas (GHG) emissions when continuous flooding of paddy soils is halted and other rice-growing practices are modified. Methane (CH4) emissions decrease by 22% to 64% as intermittent irrigation (or alternate wetting and drying, AWD) provides soils with more time under aerobic conditions (Gathorne-Hardy et al. 2013, 2016; Choi et al. 2015; Jain et al. 2014; Suryavanshi et al. 2013; Wang 2006; Dill et al. 2013).

Regenerative Grazing

68% of the world’s agricultural lands are rangelands that are mostly unsuitable for cropping, as tillage severely erodes soils. These ecosystems have been traditionally managed by pastoralists. They currently support over 2 billion people and are among the most degraded agroecosystems on the planet.

Many systems, known by different names, fall under the heading of regenerative grazing, such as AMP grazing, cell grazing, mob grazing, rotational grazing, and Holistic Planned Grazing.

Allan Savory is the leading pioneer of regenerative grazing. He developed the Holistic Planned Grazing method, which is still used today, and inspired many other regenerative grazing systems. This method, which employs livestock grazing to restore biodiversity, has consistently proven successful on every continent with arable land for over fifty years.

Allan understood that this was the solution for restoring rangelands. While overgrazing occurs when animals graze too long and are moved before the ecosystem can recover, grazing animals briefly, if given enough time for vegetation to recover, mimics natural herding systems and boosts biodiversity. Even a low stocking density of animals that constantly browse their preferred species can damage plants because they never get a chance to recover. (Butterfield, J., Bingham, S., and Savory, A. 2006)

Researchers found that the adoption of regenerative agriculture systems produced considerable ecological and biodiversity benefits. “Incorporating forages and ruminants into regeneratively managed agroecosystems can elevate soil organic C [SOM], improve soil ecological function by minimizing the damage of tillage and inorganic fertilizers and biocides, and enhance biodiversity and wildlife habitat. We conclude that to ensure long-term sustainability and ecological resilience of agroecosystems, agricultural production should be guided by policies and regenerative management protocols that include ruminant grazing.” (Teague et al. 2016)

Researchers using regenerative grazing practices in the southeastern United States stated that it increased “…cation exchange and water holding capacity by 95% and 34%, respectively. Thus, within a decade of management-intensive grazing practices soil C [SOM] levels returned to those of native forest soils, and likely decreased fertilizer and irrigation demands. Emerging land uses, such as management-intensive grazing, may offer a rare win–win strategy combining profitable food production with rapid improvement of soil quality and short-term climate mitigation through soil C-accumulation.” (Machmuller et al. 2015)

These regenerated grazing lands showed notable improvements in SOM, soil fertility, water retention, and biodiversity, enabling support for more livestock and improving the well-being of local communities. (Teague et al. 2011)

Allan Savory has made a significant contribution to this effort. He founded the Savory Institute, now based in Denver, Colorado; the Africa Centre for Holistic Management near Victoria Falls, Zimbabwe; and Holistic Management International, headquartered in Albuquerque, New Mexico. These organizations work with ranchers and farmers worldwide to expand Holistic Planned Grazing across every continent. As of now, there are 54 “Savory Hubs” in 30 countries, with 203 accredited professionals who have trained 15,755 land managers on 55 million acres (22 million hectares) of land.

Traditional Small Holder Farmer Yields

Most of the 3 billion people who earn a living from agriculture farm on 5 acres (2 hectares) or less and live in extreme poverty. 80 years of industrial agriculture haven’t improved their situation. Research shows that traditional smallholder farming systems see higher yields when they use well-practiced organic methods. Significant yield gains can be achieved by teaching these farmers to adopt science-based regenerative organic practices into their traditional techniques, including:

  • Improved soil nutrition through the recycling of soil organic matter (SOM) and proper mineral balance.
  • Improved pest and disease control
  • Water use efficiency, especially increasing soil organic matter
  • Better weed control methods
  • Eco-function intensification: increasing the diversity of systems

This is very important information because the overwhelming majority of the world’s farmers fall into this category. A report by the United Nations Conference on Trade and Development (UNCTAD) and the United Nations Environment Programme (UNEP), which reviewed 114 projects in Africa covering 2 million hectares and 1.9 million farmers, found that organic agriculture increases yields in Africa. ‘…the average crop yield was … 116 per cent increase for all African projects and 128 per cent increase for the projects in East Africa.’ (UNEP-UNCTAD, 2008).

The report notes that despite the introduction of industrial agriculture in Africa, food production per person is now 10% lower than it was in the 1960s. ‘The evidence presented in this study supports the argument that organic agriculture can be more conducive to food security in Africa than most industrial production systems, and that it is more likely to be sustainable in the long term.’ Supachai Panitchpakdi, Secretary General of UNCTAD and Achim Steiner, Executive Director of UNEP stated. (UNEP-UNCTAD, 2008). 

Eco-functional Intensification (EFI)

Eco-functional intensification (EFI) enhances ecosystem services by leveraging functional biodiversity. These regenerative organic systems rely on ecological processes rather than chemical intensification. EFI involves applying the science of agroecology to actively boost biodiversity in agricultural systems to provide ecosystem services, instead of using the industrial approach that depends on reductionist monocultures and externally sourced toxic synthetic inputs.

The Push–Pull method in maize exemplifies an innovative EFI approach that combines various ecological factors to significantly boost yields. This is important because maize is a primary food source for smallholder farmers across many parts of Africa, Latin America, and Asia. Corn stem borers are among the most damaging pests for maize. Industrial agriculture often depends on toxic synthetic pesticides to manage these pests. Recently, it has also begun to use genetically engineered varieties that produce their own pesticides. The Push-Pull system was developed by scientists in Kenya at the International Centre of Insect Physiology and Ecology (ICIPE), Rothamsted Research in the UK, along with other partners.

Silver Leaf Desmodium is planted in the crop to repel stem borers and to attract the natural enemies of the pest. The Desmodium releases phenolic compounds that repel the stem borer moth. Its root exudates also inhibit the growth of many weed species, including Striga, a serious parasitic weed of maize. The ability of functional biodiversity to suppress weeds while benefiting the cash crop is part of an emerging ecological science called selective allelopathy.

Napier grass is planted outside of the field as a trap crop for the stem borer. The Desmodium repels (pushes) the pests from the maize, and the Napier grass attracts (pulls) the stem borers out of the field to lay their eggs in it instead of the maize. The sharp silica hairs on the Napier grass also kill the stem borer larvae when they hatch, breaking the life cycle and reducing pest numbers.

High yields are not the only advantages. The system does not need synthetic nitrogen because Desmodium is a legume that fixes nitrogen. Soil erosion is prevented by a permanent ground cover. Importantly, the system offers quality fodder for livestock. One farmer innovation to enhance this system has been to systematically harvest the edges of Napier grass and Desmodium to use as fresh fodder for animals. Livestock can also graze the field after the maize is harvested. Many Push-Pull farmers include a dairy cow in the system and sell excess milk to create a steady income.

Push-Pull has been adapted to work with numerous other crops such as millet, sorghum, wheat, vegetables, and fruit trees. 

Tigray, Ethiopia – Biogas and Higher Crop Yields

A notable example of eco-functional intensification is a project led by the Institute of Sustainable Development in Tigray, Ethiopia. They partnered with farmers to revegetate the land and restore the local ecology and water systems. The biomass produced from this revegetation was then sustainably harvested to make compost and supply biogas digesters.

Revegetating marginal areas like watercourses, gullies, steep slopes, roadsides, laneways, and field borders, along with sustainably harvesting biomass, provides a consistent source of nutrients beyond those produced by good regenerative organic practices in the fields. This is especially crucial for building soil fertility and replacing nutrients lost when crops are exported from the farm. When combined with functional biodiversity—such as deep-rooted legumes for nitrogen fixation, host plants for natural enemies of pest species, and taller plants as windbreaks—these revegetated marginal areas deliver a variety of valuable ecosystem services.

The use of biogas provided significant energy independence for the villages by supplying all the gas needed for cooking and lighting, while also reducing the need to cut down vegetation for fires. The compost residues from the biogas digesters were applied to the crop fields. As a result, over several years, yields increased by more than 100%, and water use efficiency improved, transforming communities that faced periodic famines—causing suffering and loss, especially among children—into areas of prosperity and well-being.

Better Pest and Disease Resistance

The farmers also discovered that the systems using compost exhibited greater resistance to pests and diseases in the crops.

The field on the left side was treated with compost and did not suffer from rust. The field on the right side, which was treated with chemical fertilizers, suffers from rust.

The chemical fertilizer field needed to be sprayed with fungicides and produced 1.6 tons of wheat per hectare.

Wheat treated with compost resisted rust and produced 6.5 tons per hectare.

The farmers used seeds from their own landraces, which had been developed over thousands of years to adapt locally to the climate, soil, and major pests and diseases. The best of these farmer-bred varieties demonstrated a strong ability to produce high yields under regenerative organic conditions. A key benefit of this system was that the seeds and compost were sourced locally at little or no cost to the farmers, whereas seeds and synthetic chemical inputs in industrial systems had to be purchased. Not only did the organic system yield higher returns, but it also provided better overall net gains for the farmers. (Edwards et al. 2011)

 Multiple studies show high yields and positive environmental effects.

The above examples show that the assumption that greater inputs of synthetic chemical fertilizers and toxic pesticides are needed to increase food yields is not accurate. In a study published in The Living Land, Professor Pretty looked at projects in seven industrialized countries of Europe and North America. ‘Farmers are finding that they can cut their inputs of costly pesticides and fertilisers substantially, varying from 20-80%, and be financially better off. Yields do fall to begin with (by 10-15% typically), but there is compelling evidence that they soon rise and go on increasing. In the USA, for example, the top quarter sustainable agriculture farmers now have higher yields than industrial farmers, as well as a much lower negative impact on the environment.’ (Pretty, 1999).

Regenerative, organic, and agroecological farming systems have often been overlooked by the scientific research community; however, this is changing as studies show these systems can produce yields equal to or higher than those of industrial agriculture. Below are numerous examples of research into these systems that demonstrate high yields and positive environmental effects.

 US Agricultural Research Service (ARS) Pecan Trial

The ARS organically managed pecans outperformed the industrially managed, chemically fertilized, and pesticide-contaminated orchard over the past five years. Yields at ARS’s organic test site exceeded those of the industrial orchard by 18 pounds of pecans per tree in 2005 and by 12 pounds per tree in 2007. (Bradford J.M., 2008)

The Wisconsin Integrated Cropping Systems Trials

The Wisconsin Integrated Cropping Systems Trials found that organic yields were higher during drought years and comparable to industrial yields in normal weather years.

In years with wet spring weather, organic yields can decline when mechanical weeding is delayed, leading to a 10% drop. This problem can be fixed by using steam or vinegar instead of tillage for weed control.

The researchers attributed the higher yields during dry years to the soil of organic farms being able to absorb rainfall more quickly. This is because of the increased levels of SOM, which make soils more friable and better at storing and capturing rain. (Posner et al., 2008)

The Rodale Institute’s 40-Year Report on their Farming Systems Trial

The Rodale Institute’s 40-Year-Report on their Farming Systems Trial should dispel the myth of toxic GMO herbicide no-till systems. Rodale’s scientific trials clearly demonstrate that these degenerative no-till methods are worse than Regenerative Organic Agriculture on every major point. Very significantly, 40 years of research show that organic maize yields have been 31 percent higher than industrial/industrial farming systems in drought years. (Rodale 2022)

Scientific Review by Cornell University of the Rodale Field Study

The scientific review found:

  • The improved soil allowed the organic land to generate yields equal to or greater than those of the industrial crops after 5 years
  • The yield of the industrial crops collapsed during drought years.
  • The organic crops fluctuated only slightly during drought years, due to greater water-holding capacity in the enriched soil.
  • The organic crops used 30% less fossil energy inputs than the industrial crops, resulting in significant cost savings. (Pimentel et al., 2005).
Rodale Organic Low/No Till

The Rodale Institute has been trialing a range of organic low tillage and no tillage systems. The 2006 trials resulted in organic yields of 160 bushels an acre (bu/ac) compared to the County average of 130 bu/ac. ‘..the average corn yield of the two organic no-till production fields was 160 bu/ac, while the no-till research field plots averaged 146 bu/ac over 24 plots. The standard-till organic production field yielded 143 bu/ac, while the Farming Systems Trial’s (FST’s) standard-till organic plots yielded 139 bu/ac in the manure system (which received compost but no vetch N inputs) and 132 bu/ac in the legume system (which received vetch but no compost). At the same time, the FST’s non-organic standard-till field yielded 113 bu/ac…To compare, the Berks County average non-organic corn yield for 2006 was 130 bu/ac, and the average yield for Southeastern Pennsylvania was 147 bu/ac’ (Rodale, 2006).

Maize is planted into vetch that has been crushed with a roller. This organic no-till maize produced 160 bushels per acre (bu/ac), surpassing the county average of 130 bu/ac.

Iowa Trials

The results from the Long-Term Agroecological Research (LTAR), a 12-year collaborative effort between producers and researchers led by Dr. Kathleen Delate of Iowa State University, show that organic systems can produce yields equal to or higher than industrial systems. Consistent with several other studies, the data indicated that although organic systems had lower yields at first, by year four, they began to outperform the industrial crops. Across all rotations, organic corn harvests averaged 130 bushels per acre, while industrial corn yielded 112 bushels per acre. Similarly, organic soybean yield was 45 bu/ac compared to the industrial yield of 40 bu/ac in the fourth year. (Delate, 2010)

Overview by the United Nations Food and Agriculture Organization (FAO)

FAO conducted an extensive study of global trends in scientific literature. They found significant evidence of substantial increases in yields in regenerative, organic, and agroecological systems.

The section below is based on quotes from their document:

The Main benefits

The main benefit of implementing improved cropland management practices is expected to be higher and more stable yields, increased system resilience and, therefore, enhanced livelihoods and food security, and reduced production risk (Conant 2010; Vallis et al. 1996; Pan et al. 2006; Woodfine 2009; Thomas 2008).

Cover Crops

Use of cover crops is reported to lead to higher yields due to decreased on-farm erosion and nutrient leaching, and reduced grain losses due to pest attacks. For example: Kaumbutho et al. (2007) showed that maize yield increased from 1.2 to 1.8-2.0 t/ha in Kenya with the use of mucuna (Velvet Bean) cover crop; Olaye et al. (2007) showed that there was a significant yield loss of about 31.4-42.4% in the long run and 36.7-48.5% in the short run for continuous maize planting compared to maize cropped using different cover crop types—Cajanus spp. (e.g. Pigeon pea) and mucuna; Pretty (2000) showed that farmers who adopted mucuna cover cropping benefited from higher yields of maize with less labour input for weeding (maize following mucuna yields 3-4 t/ha without application of nitrogen fertiliser, similar to yields normally obtained with recommended levels of fertilisation at 130 kgN/ha); Altieri (2001) reported that maize yields in Brazil increased by 198-246% with the use of cover crops. 

Crop rotations

Crop rotations and intercropping designed to ensure differential nutrient uptake and use – e.g. between crops, such as millet and sorghum and Nitrogen-fixing crops, such as groundnuts, beans and cowpeas – will enhance soil fertility, reduce reliance on chemical fertilizers, and enrich nutrient supply to subsequent crops (Conant 2010), leading to increased crop yields (Woodfine 2009). For example, Hine and Pretty (2008) showed that in the North Rift and western regions of Kenya maize yields increased to 3,414 kg/ha (71% increase in yields) and bean yields to 258 kg/ha (158% increase in yields); Hodtke et al. (undated), as cited by Parrot and Marsden (2002), report that, in Brazil, intercropping maize with legumes led to increases in both grain yield and total nitrogen content by 100%.

Increased crop yields after a fallow period have been widely reported (Agboola 1980; Hamid et al. 1984; Saleen and Otsyina 1986; Prinz 1987; Palm et al. 1988; Conant 2010), although the magnitude of yield increment after each successive fallow is variable, and bare fallow may increase soil erosion risk.

Improved Crop Varieties

The use of improved crop varieties is expected to increase average yields because of the greater seed diversity of the same crop. For example, Pretty (2000) showed that introduction of new varieties of crops (vegetables) and trees (fruits) increases yields in Ethiopia by 60%; the International Centre for Tropical Agriculture (CIAT 2008) showed that the average yield increase due to the introduction of new bean varieties in seven African countries was 44% in 2004-2005, although the gains varied widely across countries, ranging from 2% in Malawi to 137% in western Kenya.

Adopting Organic Fertilization

Adopting organic fertilization (compost and animal manure) is widely found to have positive effects on the yields. For example, Hine and Pretty (2008) showed that maize yields increased by 100% (from 2 to 4 t/ha) in Kenya; Parrot and Marsden (2002) showed that millet yields increased by 75-195% (from 0.3 to 0.6-1 t/ha) and groundnut by 100-200% (from 0.3 to 0.6-0.9 t/ha) in Senegal; and Scialabba and Hattam (2002) showed that potato yields increased by 250-375% (from 4 to 10-15 t/ha) in Bolivia. Altieri (2001) quotes several examples from Latin America where adoption of organic fertilization and composting led to increases in maize/wheat yields between 198-250% (Brazil, Guatemala and Honduras) and in coffee yield by 140% (in Mexico); Edwards (2000) showed that in the Tigray province of Ethiopia, composting led to yield increases compared to chemically fertilized plots: barley (+9%), wheat (+20%), maize (+7%), teff (+107%), and finger millet (+3%); Rist (2000), as cited in Parrott and Marsden (2002), reports that farmers in Bolivia increased potato yields by 20% using organic fertilizers. Also, enhancing inputs of nitrogen through nitrogen-fixing plants that are not harvested (green manure) is key to maximizing production and ensuring long- term sustainability of agricultural systems (Fageria 2007; Hansen et al. 2007). For example, Kwesiga et al. (2003) showed that in Zambia, including Sesbania sesban (an indigenous nitrogen-fixing tree) fallow in rotation led to increases in yields for maize with respect to continuous cropping. Maize yields increased from 6.75 to 7.16 and 7.57 t/ha following 1, 2 and 3 years fallow, showing that short leguminous fallow rotations of 1-3 years have the potential to increase maize yields even without fertilizers, thanks to the nitrogen-fixation capacity and mineralization of the belowground root system.

Increasing the proportion of nutrients retained in the soil – e.g. through mulching and limiting nutrient leaching – is also expected to have positive effects on crop yields (Smolikowski et al. 1997; Conant 2010; Silvertown et al. 2006). For example, Lal (1987) reported yield increases by incorporating residue mulch of rice husks (about 6 t/ha) on different crops—from 3.0 to 3.7 t/ha on maize, 0.6 to 1.1 t/ha on cowpea, 0.6 to 0.8 t/ha on soybean, 16.4 to 28.3 t/ha on cassava and 10.7 to 17.9 t/ha on yam. Also, soil water contents are generally higher under mulch cover (Unger et al. 1991; Arshad et al. 1997; Barros and Hanks 1993; Scopel et al. 2004).

Conclusion

Regenerative and organic agriculture based on agroecology science can help countries become self-sufficient in food, boost exports, create trade surpluses, and improve everyone’s economic well-being. These systems produce higher yields, especially during climate extremes like drought and heavy rainfall.

Numerous peer-reviewed scientific studies show that pesticides are insufficiently tested for safety and are associated with many diseases impacting our society, especially in children. (Leu 2018)

Regenerative and organic agriculture, grounded in agroecology science, enhances yields in farming systems when combined with innovation and scientific expertise. Research indicates that organic and SRI systems yield greater rice outputs. A United Nations study has found that organic agriculture increases yields in traditional African systems by more than 100%. Additionally, other published scientific studies show that effective regenerative organic practices can achieve yields equal to or greater than those of industrial systems with proper management.

Regenerative and organic agriculture founded on agroecology science serves as a sustainable economic model because of its lower input costs. Most inputs for soil health and managing pests, diseases, and weeds can be produced on the farm or sourced locally at minimal or no expense. This removes the need for expensive imported synthetic pesticides and fertilizers. Additionally, using organic matter to produce biogas not only promotes energy independence but also results in residues that can boost crop yields by over 100%.

References

Bachman L, Cruzada E, Wright S, (2009), Food Security and Farmer Empowerment, MASIPAG, 2611 Carbern Village, Anos Los Banos, Laguna 4000, Philippines, 2009, ISBN 078-971-94381-0-6

Branca G, McCarthy N, Lipper L and Jolejole M C, (2011) Climate-Smart Agriculture: A Synthesis of Empirical Evidence of Food Security and Mitigation Benefits from Improved Cropland Management, Food and Agriculture Organization of the United Nations (FAO)  December 2011

Bradford J.M. (2008), Organic Pecans: Another Option for Growers. November/December 2008, Agricultural Research magazine. US Agricultural Research Service (ARS). http://www.ars.usda.gov/is/AR/archive/nov08/pecans1108.htm?pf=1

Butterfield, J., Bingham, S., and Savory, A. (2006). Holistic Management Handbook:

Healthy Land, Healthy Profits. Washington, DC: Island Press.

Cacek T. and Langner L.L. (1986), The economic implications of organic farming, 1986, American Journal of Alternative Agriculture, Vol. 1, No. 1, pp. 25-29. http://eap.mcgill.ca/MagRack/AJAA/AJAA_2.htm

Delate K. and Cambardella C.A. (2004), Organic production: Agroecosystem performance during transition to certified organic grain production. Agronomy Journal, 2004, 96, pp. 1288-1298.

http://naldc.nal.usda.gov/download/8283/PDF

Delate K. (2010), Sources: http://www.twnside.org.sg, http://www.biosafety-info.net,

http://www.non-gmoreport.com/articles/feb10/organic_corn_soybean_yields_exceed industrial.php

Drinkwater L. E., Wagoner P. & Sarrantonio M. (1998), Legume-based cropping systems have reduced carbon and nitrogen losses. Nature, 396, pp. 262-265. http://www.nature.com/nature/journal/v396/n6708/abs/396262a0.html

Edwards S., Egziabher T. & Araya H. (2011), Successes and Challenges in Ecological Agriculture: in Experiences from Tigray, Ethiopia, Eds. Lim L.C., Edwards S. and El-Hage Scialabba N., in Climate Change and Food Systems Resilience in Sub-Saharan Africa, Food and Agriculture Organization of the United Nations, ISBN 978-92-5-106876-2. www.fao.org/docrep/014/i2230e/i2230e09.pdf

LaSalle T and Hepperly P (2008). Regenerative organic farming: A solution to global warming. The Rodale Institute, Kutztown, PA, USA, p 5.

Leu, Andre, (2018) Poisoning our Children, the parents’ guide to the myths of safe pesticides, Acres U.S.A. Greely, Colorado, USA 2018, ISBN 978-1-601-73140-1.

Lotter DW, Seidel R and Liebhart W (2003). The performance of organic and industrial cropping systems in an extreme climate year. American Journal of Alternative Agriculture, 18(3):146–154.

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Rodale 2022, Farming Systems Trial 40-YEAR REPORT, Rodale Institute, https://rodaleinstitute.org/science/farming-systems-trial, Accessed December 8, 2022

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Glyphosate and GMOs Are Damaging Our Health. It’s Time to Ban Them

The Scientific Evidence That Justifies Banning GMOs and Glyphosate

There are an enormous number of published scientific studies showing that GMOs and their associated pesticides are responsible for multiple serious health problems for people, animals, and the wider environment.

The widespread adoption of GMO crops in the U.S. has resulted in a massive increase in the application of glyphosate, the active ingredient in Roundup, as the primary method of weed control. [1]

A landmark study on glyphosate by Panzacchi et al. was published on June 10, 2025, examining total lifetime exposure to the so-called ‘safe’ levels to which most people are subjected [2].

The study found that the lowest dose of 0.5 mg/kg, which is four times lower than the US Environmental Protection Agency’s (EPA) proposed ‘safe’ level, led to increased rates of both benign and malignant tumors at various anatomical sites compared to the controls. These tumors included leukemia, skin, liver, thyroid, nervous system, ovary, mammary gland, adrenal glands, kidney, urinary bladder, bone, endocrine system, pancreas, uterus, and spleen. [2,3]

This study confirms evidence from earlier research, including that by the IARC and Seralini et al., among many others[4,5]. It also validates the accuracy of “Genetically engineered crops, glyphosate and the deterioration of health in the United States of America,” where Dr. Nancy Swanson, our co-authors, and I demonstrated how glyphosate and GMOs are linked to over 20 chronic diseases in the U.S [1].

The First Credible Peer-reviewed Lifetime Study of GMOs and Roundup

Until Panzacchi et al. was published, there was only one credible, independent, non- industry funded, peer-reviewed lifetime feeding study of GMOs and Roundup. It found that mammary and other tumors, liver and kidney damage result from regular exposure to minute amounts of Roundup and/or a diet containing GMO corn, similar to the typical exposures people get from food. [5]

The image above shows a rat with large mammary tumors caused by consuming glyphosate at the usual levels found in food. The tumors on the right-hand side, starting from the top, are caused by eating GMO corn, GMO corn treated with Roundup, or just Roundup. (Seralini et al.)

All female rats in the study that were fed GMOs and/or Roundup (Treated Group) developed mammary tumors and died earlier than the rats fed non-GMO food without Roundup (Control Group), except for one rat that died early from an ovarian tumor. This finding aligns with Thongprakaisang et al., showing that glyphosate promotes the growth of human breast cancer cells via estrogen receptors. [6]

Treated males presented four times the number of tumors that were large enough to be felt by hand than the controls, and these occurred up to six hundred days earlier.

The International Agency for Research on Cancer (IARC)

The International Agency for Research on Cancer (IARC) has assigned glyphosate a rating of Group 2A for Cancer, the second-highest classification. [4]

This means it causes cancer in animals and has some evidence of causing cancer in humans, most notably non-Hodgkin lymphoma.

A study by Flower et al. examined the levels of cancer in children whose parents used glyphosate for weed control. They found that these children had increased levels of all childhood cancers, including all lymphomas, such as non-Hodgkin lymphoma.[7]

A case-controlled study by Swedish scientists Lennart Hardell and Mikael Eriksson also linked non-Hodgkin lymphoma to exposure to various pesticides and herbicides, including glyphosate. [8] The link between glyphosate and non-Hodgkin lymphoma has resulted in significant court cases, most of which Bayer-Monsanto has lost and awarded millions of dollars to the victims.

Genetically engineered crops, glyphosate, and the deterioration of health in the United States of America
Dr. Nancy Swanson, myself, and co-authors Jon Abrahamson and Bradley Wallet published a peer-reviewed paper, “Genetically engineered crops, glyphosate, and the deterioration of health in the United States of America,” showing how glyphosate and GMOs are linked to over 20 diseases in the U.S. The study searched US government databases for genetically engineered crop data, glyphosate application data, and disease epidemiological data. This was correlated with numerous diseases linked to the increased use of glyphosate and GMOs. A standard accepted statistical analysis showed that the odds of glyphosate and GMOs not being the cause of these diseases was 10,000 to 1. On top of these, numerous studies are confirming the link between GMOs and glyphosate with these diseases. [1]

We compiled this data into graphs demonstrating the rise in diseases, glyphosate, and GMOs. We also included green trend lines to illustrate that these increases are linked to the growing use of genetically engineered (GE) corn and soy, along with glyphosate.

Correlations with Cancer
We found strong correlations for cancers of the liver, kidney, thyroid, and pancreas, as well as deaths from acute myeloid leukemia. These correlations have now been confirmed by Panzacchi et al., who demonstrated that small levels of glyphosate and glyphosate herbicides cause these issues in rats.

Thyroid cancer, in particular, appears to be linked to the introduction of GE crops and the use of glyphosate. It seems to affect women more, while men are more susceptible to liver and kidney cancers.

Autism and Dementia
Autism and dementia have reached epidemic levels in the U.S. The chart below clearly indicates the connection between the sharp increase in glyphosate and GMOs since the 1990s and the rise in these diseases.

Researchers have shown how exposure to minute amounts of glyphosate damages the normal development of nerves.

The image above shows how glyphosate harms nerve development. The cells exposed to glyphosate had shorter, unbranched axons (the long ‘arms’ of the nerve) and less complex dendritic arbors (the smaller ‘fingers’ extending from the cell body). It is clear from the image that the glyphosate-exposed cells do not develop properly and, therefore, cannot function effectively. [9]

The scientists identified how glyphosate impacts nerve development and stated that it cannot be reversed. The main concern is that the brain, the largest network of nerves in the human body, is still developing in unborn, newborn, and growing children. Exposure to small amounts of glyphosate in food can negatively affect the brain’s normal development, leading to major issues seen in children, such as autism spectrum disorder, bipolar spectrum disorder, ADHD, and other developmental and behavioral problems.

Adult brains are constantly renewing brain cells. These nerve cells are also adversely affected by glyphosate. The graph above shows a very strong link between the increase in glyphosate and deaths from dementia.

Endocrine Disruption – Disruption to Hormones
Gasnier et al. reported endocrine-disrupting actions of glyphosate at 0.5 ppm. According to the authors, this is “800 times lower than the level authorized in some food or feed (400 ppm, USEPA, 1998).” [10]

Professor Séralini’s study published in Environmental Sciences Europe found that both GM maize and Roundup act as endocrine disruptors, and their consumption led to female rats dying—at a rate two to three times higher than the control animals.

The pituitary gland was the second most affected organ, and the sex hormone balance was altered in females fed with the GMO and Roundup treatments. [4]

Disruption of Metabolic Pathways
One of the most important studies was published by Samsel and Seneff in the peer- reviewed scientific journal Entropy in 2013. This detailed review, titled “Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases,” demonstrated how glyphosate disrupted many biochemical pathways in the human body, including those of gut microorganisms, which could potentially lead to various diseases. [11]

Studies show that disruptions of the normal hormone and metabolic pathways are major causes of obesity, in that they disrupt the normal control mechanisms that stop overeating. Science clearly shows that glyphosate is one of these chemicals.

Diabetes
The rise in diabetes is directly connected to obesity. Most obese people develop diabetes because they overload the hormonal systems that control blood sugar. Over time, these systems begin to fail, leading to dangerous spikes in blood sugar.

Disruption of the Gut Microbiome

Samsel and Seneff’s paper identified how glyphosate disrupted the gut microbiome, causing the suppression of biosynthesis of cytochrome P450 enzymes and key amino acids. In a later paper, “Glyphosate, Pathways to Modern Diseases II: Celiac Sprue and Gluten Intolerance,” Samsel and Seneff showed that the current increase in celiac disease and gluten intolerance in people was linked to glyphosate’s adverse effects on the gut microbiome. They highlighted that glyphosate is patented as a biocide, and consequently, it kills the beneficial gut bacteria, leading to a rise in intestinal diseases. [12]

Krüger et al. showed that glyphosate affects the microbiome of horses and cows. Shehata et al. found the same effects in poultry; the researchers state, “Highly pathogenic bacteria such as Salmonella Entritidis, Salmonella Gallinarum, Salmonella Typhimurium, Clostridium perfringens and Clostridium botulinum are highly resistant to glyphosate. However, most of beneficial bacteria as Enterococcus faecalis, Enterococcus faecium, Bacillus badius, Bifidobacterium adolescentis and Lactobacillus spp. were found to be moderate to highly susceptible.” Both groups of researchers postulated that glyphosate is associated with the increase in botulism- mediated diseases in these domestic farm animals. [13,14]

Inflammatory bowel diseases are rising along with deaths from intestinal infections. Glyphosate’s disruption of the gut microbiome must be seen as a significant cause.

Kidney and Liver Disease
Kidney and liver diseases are major chronic diseases. The graph below clearly shows the relationship between GMOs, glyphosate, and the rapid increase in deaths from kidney disease in the U.S. Deaths from kidney disease fell until the widespread increase of glyphosate and GMOs.

In the lifetime feeding study of rats conducted by Séralini et al. the treated males displayed liver congestions and necrosis at rates 2.5 to 5.5 times higher than the controls, as well as marked and severe kidney nephropathies (kidney damage) at rates generally 1.3 to 2.3 greater than the controls.[5]

The image above shows kidneys and livers that have been damaged by Roundup (glyphosate), GMO corn, and both. In a later published study designed to understand why Roundup and glyphosate-based herbicides caused kidney and liver damage in rats, scientists discovered that ultra-low doses of these herbicides disrupted numerous genes’ functions, resulting in changes consistent with multiple kidney and liver disease problems.

The researchers stated, “Our results suggest that chronic exposure to a GBH (glyphosate-based herbicides) in an established laboratory animal toxicity model system at an ultra-low, environmental dose can result in liver and kidney damage with potential significant health implications for animal and human populations.” [15]

Conclusion
Research shows that GMOs and glyphosate cause multiple serious chronic diseases. Over 50 years of regulation since glyphosate’s introduction in 1974 clearly highlight regulatory failure. Authorities should fulfill their duty to protect the public by banning these substances.

References

1. Nancy L. Swanson, Andre Leu, Jon Abrahamson, and Bradley Wallet, Genetically engineered crops, glyphosate and the deterioration of health in the United States of America, Journal of Organic Systems, 9(2), 2014

2. Panzacchi, S., Tibaldi, E., De Angelis, L. et al. Carcinogenic effects of long- term exposure from prenatal life to glyphosate and glyphosate-based herbicides in Sprague–Dawley rats. Environ Health 24, 36 (2025).

3. EPA R.E.D. FACTS Glyphosate, https://www3.epa.gov/pesticides/ chem_search/reg_actions/reregistration/fs_PC-417300_1-Sep-93.pdf

4. “Glyphosate,” IARC Monographs–112, http://monographs.iarc.fr/ENG/ Monographs/\vol112/mono112-02.pdf.

5. Gilles-Éric Séralini et al., “Long-Term Toxicity of a Roundup Herbicide and a Roundup-Tolerant Genetically Modified Maize, Environmental Sciences Europe, republished study (2014): 14.

6. Thongprakaisang, S., Thiantanawat, A., Rangkadilok, N., Suriyo, T. and Satayavivad, J., 2013, Glyphosate induces human breast cancer cells growth via estrogen receptors, Food and Chemical Toxicology, 59: 129-136.

7. K. B. Flower, J. A. Hoppin, C. F. Lynch, A. Blair, C. Knott, D. L. Shore, et al., “Cancer Risk and Parental Pesticide Application in Children of Agricultural Health Study Participants,” Environmental Health Perspectives 112, no. 5 (2004): 631–35.

8. Lennart Hardell and Mikael Eriksson, “A Case-Control Study of Non- Hodgkin Lymphoma and Exposure to Pesticides,” Cancer 85, no. 6 (March 15, 1999): 1353–60.

9. Romina P. Coullery, María E. Ferrari, Silvana B. Rosso, Neuronal development and axon growth are altered by glyphosate through a WNT non- canonical signaling pathway, NeuroToxicology 52 (2016) 150–161

10. Céline Gasnier et al., “Glyphosate-Based Herbicides are Toxic and Endocrine Disruptors in Human Cell Lines,” Toxicology 262 (2009): 184–91

11. Anthony Samsel and Stephanie Seneff, “Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases,” Entropy 15, no. 4 (2013): 1416–63.

12. Anthony Samsel and Stephanie Seneff, “Glyphosate, Pathways to Modern Diseases II: Celiac Sprue and Gluten Intolerance,” Interdisciplinary Toxicology 6, no. 4 (2013):159–84, http://sustainablepulse.com/wp-content/uploads/2014/02/ Glyphosate_II_Samsel-Seneff.pdf (accessed March 21, 2014).

13. Monika Krüger, Awad Ali Shehata, Wieland Schrödl, and Arne Rodloff, “Glyphosate Suppresses the Antagonistic Effect of Enterococcus spp. on Clostridium botulinum,” Anaerobe 20 (April 2013): 74–78.

14. Awad Ali Shehata, Wieland Schrödl, Alaa A. Aldin, Hafez M. Hafez, and Monika Krüger, “The Effect of Glyphosate on Potential Pathogens and Beneficial Members of Poultry Microbiota in Vitro,” Current Microbiology 66, no. 4 (2012): 350– 58.

15. Robin Mesnage, Matthew Arno, Manuela Costanzo, Manuela Malatesta, Gilles-Éric Séralini, and Michael N. Antoniou, “Transcriptome Profile Analysis Reflects Rat Liver and Kidney Damage Following Chronic Ultra-Low Dose Roundup exposure,” Environmental Health 14 (2015): 70.

Organic Food – Protecting Our Children

The current regulatory systems have failed to protect children and the wider population from diseases caused by pesticides. It is important to remember that the majority of people get their exposure to pesticides from food. Most people, including children, carry a body burden of a cocktail of these toxic chemicals with no scientific evidence that they are safe. However, there is ample evidence that these chemicals are harming our children [1]. As an example, the latest study on glyphosate shows that residue levels four times lower than the EPA’s ‘safe level’ cause numerous cancers, including hemolymphoreticular tissues (leukemia), skin, liver, thyroid, nervous system, ovary, mammary gland, adrenal glands, kidney, urinary bladder, bone, endocrine pancreas, uterus, and spleen (hemangiosarcoma).[2]

Currently, for consumers, the only way to avoid synthetic pesticides is to eat organically grown food. Most children are exposed to pesticides either directly by consuming food with pesticide residues or indirectly through the placenta and breast milk, as a result of pesticides in their mothers’ food. Multiple scientific studies show that consuming organic food is the most effective way to protect children, as most pesticide exposure occurs through the consumption of food from industrial farming systems.

Glyphosate is the most widely used pesticide in the USA, and most people carry residues of it in their bodies. It is linked to numerous diseases. [3]  A study published in Environmental Research concluded, “An organic diet was associated with significantly reduced urinary levels of glyphosate and AMPA.” [4]

The researchers found that “The reduction in glyphosate and AMPA levels was rapid, dropping to baseline within three days. This study demonstrates that diet is a primary source of glyphosate exposure and that shifting to an organic diet is an effective way to reduce body burden of glyphosate and its main metabolite, AMPA.”
 [4]

This study contributes to a growing body of published scientific research that demonstrates an organic diet reduces exposure to a range of pesticides in children and adults.

A study published in Environmental Health Perspectives found that children who consume organic fruits, vegetables, and juices can significantly reduce the levels of organophosphate pesticides in their bodies. The University of Washington researchers who conducted the study concluded,

“The dose estimates indicate that consuming organic fruits, vegetables, and juice can decrease children’s exposure levels from above to below the U.S. Environmental Protection Agency’s current guidelines, thereby shifting exposures from a range of uncertain risk to a range of minimal risk”.

“Consumption of organic produce appears to provide a relatively simple way for parents to reduce their children’s exposure to OP [organophosphate] pesticides [5].”

Researchers in a 2006 study found that the urinary concentrations of the specific metabolites for malathion and chlorpyrifos decreased to undetectable levels immediately after the introduction of organic diets and remained undetectable until the conventional diets were reintroduced. The researchers from Emory University, Atlanta, Georgia; the University of Washington, Seattle, Washington; and the Centers for Disease Control and Prevention, Atlanta, Georgia, stated,

“In conclusion, we were able to demonstrate that an organic diet provides a dramatic and immediate protective effect against exposures to organophosphorus pesticides that are commonly used in agricultural production. We also concluded that these children were most likely exposed to these organophosphorus pesticides exclusively through their diet [6].”

ORGANIC FOOD IS HEALTHIER!

The largest and most comprehensive peer-reviewed scientific study comparing organic and conventional foods was published in the British Journal of Nutrition by a team of international experts from Newcastle University, UK. It clearly demonstrated that organic foods are more nutritious. This meta-study analyzed 343 published peer-reviewed studies and found that antioxidant levels were 18-69 percent higher in organic food compared to conventional food. The study showed that levels of toxic heavy metals such as lead and cadmium, as well as nitrites and nitrates, were significantly lower in organic food. [7]

Antioxidants play a crucial role in preventing oxidative stress. Oxidative stress, a hallmark of cancer, also contributes to many chronic diseases. It occurs when there is an imbalance between free radicals and the body’s ability to repair the damage caused by them. Free radicals damage various types of body cells and tissues through oxidation. Antioxidants help by “mopping up” these damaging free radical compounds, preventing them from causing harm. Numerous scientific studies demonstrate the benefits of diets rich in antioxidants, including their protective effects against cardiovascular diseases, neurodegenerative disorders, autoimmune conditions, premature aging, cancers, and many other illnesses.

Protecting Our Children and Future

The most sensible way to reduce our children’s exposure to pesticides is to avoid them as much as possible. This isn’t complicated, and it’s very straightforward to do. For most people, our primary exposure to pesticides comes from food, followed by household insect sprays and garden treatments. There are many simple, effective, non-toxic, natural methods to control bugs in the house, and many helpful books are available on this topic. Similarly, pesticides aren’t necessary for controlling bugs and weeds in the garden and on the farm, and many valuable books on this subject can be found. [8]

Research shows that eating organic food can help protect children’s health before birth. A large epidemiological study involving over 37,000 women and their children, published in Environmental Health Perspectives, found that eating organic food was associated with lower rates of hypospadias (penile malformations) and cryptorchidism (undescended testes) in baby boys, both common male urogenital birth defects. [9]

This finding is significant as the WHO-UNEP meta-study on endocrine disruptors found an increase in urogenital malformations in baby boys, such as undescended testes and penile malformations. [10] The study in Environmental Health Perspectives shows that eating organic food can protect against the adverse effects of endocrine disruptors.

Currently, for consumers, the best way to avoid these poisons is to eat organically grown food that has been produced with organic guarantee systems such as third-party certification, participatory guarantee systems (PGS), as a member of an organic CSA scheme, or farmers’ markets that check their farmers’ production claims. These guarantee systems will ensure that the food is produced without toxic compounds. Most importantly, numerous scientific studies have shown that consuming organic food leads to significantly lower levels of these pervasive chemicals in humans, particularly in children.

What is the True Cost of Foods that Contain Poison Residues?

It is time to dispel the myth that foods from farming systems using synthetic pesticides are safe to eat. This includes low- or reduced-pesticide farming methods, as there is no credible science to confirm that any level of exposure is safe. The lack of thorough testing and regulators’ blatant disregard for current science means that, until these data gaps are addressed, the most sensible choice is to avoid foods from farming systems that use these toxic chemicals.

Some people complain about the cost of organic food. However, what is the true cost of foods that contain poison residues? No amount of money can undo the damage that small amounts of pesticides are doing to our children.

The most important question is, “How much is the health of our children worth?” As parents, we have a duty to care for them by giving our children the best start in life. Good health is one of the most essential factors. Buying and eating organic food is one of the most affordable and effective ways to achieve this and ensure the best start in life for our children.

References

  1. Leu, Andre, Poisoning our Children, the parents’ guide to the myths of safe pesticides, Acres U.S.A. Greely, Colorado, USA 2018, ISBN 978-1-601-73140-1.
  2. Panzacchi, S., Tibaldi, E., De Angelis, L. et al. Carcinogenic effects of long-term exposure from prenatal life to glyphosate and glyphosate-based herbicides in Sprague–Dawley rats. Environ Health 24, 36 (2025). https://doi.org/10.1186/s12940-025-01187-2 EPA R.E.D. FACTS Glyphosate, https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_PC-417300_1-Sep-93.pdf
  3. Nancy L. Swanson, Andre Leu, Jon Abrahamson, and Bradley Wallet, Genetically engineered crops, glyphosate and the deterioration of health in the United States of America, Journal of Organic Systems, 9(2), 2014
  4. Fagan John, Larry Bohlen, Sharyle Patton, Kendra Klein, Organic diet intervention significantly reduces urinary glyphosate levels in U.S. children and adults, Environmental Research, Volume 189, 2020,
  5. Curl, Cynthia, Richard A. Fenske, and Kai Elgethun. “Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets.” Environmental Health Perspectives 111, no. 3 (March 2003): 377–382.
  6. Lu, Chensheng, Kathryn Toepel, Rene Irish, Richard A. Fenske, Dana B. Barr, and Roberto Bravo. “Organic diets significantly lower children’s dietary exposure to organophosphorus pesticides.” Environmental Health Perspectives 114, no. 2 (February 2006): 260–263.
  7. M. Baranski et al., “Higher Antioxidant Concentrations and Less Cadmium and Pesticide Residues in Organically-Grown Crops: A Systematic Literature Review and Meta-Analyses,” British Journal of Nutrition, July 15, 2014.
  8. Leu Andre, Growing Life, Acres U.S.A. Greely, Colorado, USA, 202, ISBN 978-1-60173-168-5
  9. Anne Lise Brantsæter, Hanne Torjusen, Helle Margrete Meltzer, Eleni Papadopoulou, Jane A. Hoppin, Jan Alexander, Geir Lieblein, Gun Roos, Jon Magne Holten, Jackie Swartz and Margaretha Haugen, “Organic Food Consumption during Pregnancy and Hypospadias and Cryptorchidism at Birth: The Norwegian Mother and Child Cohort Study (MoBa),” Environmental Health Perspectives, July 9, 2015, http://dx.doi.org/10.1289/ehp.1409518.
  10. Vandenberg, Laura N., Theo Colborn, Tyrone B. Hayes, Jerrold J. Heindel, David R. Jacobs Jr., Duk-Hee Lee, Toshi Shioda, Ana M. Soto, Frederick S. vom Saal, Wade V. Welshons, R. Thomas Zoeller, and John Peterson Myers. “Hormones and endocrine-disrupting chemicals: Low-dose effects and nonmonotonic dose responses.” Endocrine Reviews 33, no. 3 (June 2012): 378–455. First published ahead of print March 14, 2012, as doi:10.1210/er.2011-1050 (Endocrine Reviews 33: 0000-0000, 2012).

Hormone System Disruption

Testing shows that most foods and, consequently, people worldwide carry a mix of pesticide and chemical residues. [1] Regulatory authorities claim that these levels are safe because they are below maximum residue limits (MRLs) and the acceptable daily intake (ADI), as well as other so-called safe limits. In the previous three articles, I have shown that the methods used to assess the safety of these levels are severely inadequate for this purpose.

The current model of toxicology (the science of poisons) is based on the idea that the smaller the dose, the lesser the effect of the poison. When animal testing shows that a certain dose of poison causes no observed adverse effects (NOAEL), this dose becomes the basis for determining the ADI. The ADI is usually calculated by dividing the permitted amount by a factor of one hundred.

Regulatory authorities then contend that any residue levels below the ADI or MRL are too low to pose health risks. This model assumes that the toxic effect declines in a steady, linear fashion with lower doses until the compound is no longer toxic. It is based on Paracelsus’s maxim, the sixteenth-century physician and father of toxicology, who stated, “All things are poison and nothing is without poison; only the dose makes a thing not a poison.” This has been summarized as, “The dose makes the poison.” [1]

The fact that this five-century-old idea is still used as the basis for regulatory toxicology shows how outdated it is. To say, “All things are poison and nothing is without poison..” is completely ridiculous. For example, pure water is not a poison.

In the 1990s, this long-held myth from the horse-and-cart era that chemicals become less toxic at lower doses was conclusively disproved by evidence of low-dose endocrine (hormone) disruption. This evidence was widely disseminated through two books: Our Stolen Future and The Feminization of Nature. The peer-reviewed science summarized in these books has shown that many chemicals, including pesticides in our food, mimic hormones like estrogen and can be more toxic at lower doses[2,3]

They clearly demonstrated non-monotonic dose-response relationships, where instead of toxicity steadily decreasing, the lowest doses of some chemicals can be more toxic than higher doses. The current regulatory approach of setting the ADI by lowering the exposure threshold is therefore not a reliable safety indicator. This threshold is based on the assumption that all chemicals, including pesticides, become less toxic in a linear fashion. Minimal, if any, testing has been done at these levels to verify that this assumption holds when establishing the ADI. Until the actual ADI level is tested, there is no evidence that it is safe. Data-free assumptions are not valid science.

A major meta-review was published in 2012 by several of the world’s leading expert scientists in this field in the peer-reviewed journal Endocrine Reviews. Vandenberg et al. demonstrated that hundreds of published studies documented instances where chemicals were more toxic at low, often the lowest, doses. The scientists stated:

“We provide a detailed discussion of the mechanisms responsible for generating these phenomena, plus hundreds of examples from the cell culture, animal, and epidemiology literature. We illustrate that nonmonotonic responses and low-dose effects are remarkably common in studies of natural hormones and EDCs [endocrine-disrupting chemicals]. Whether low doses of EDCs influence certain human disorders is no longer conjecture, because epidemiological studies show that environmental exposures to EDCs are associated with human diseases and disabilities. We conclude that when nonmonotonic dose-response curves occur, the effects of low doses cannot be predicted by the effects observed at high doses.”[4]

Endocrine Disruption

Children are more vulnerable to the effects of endocrine disruptors than adults because their tissues and organs are still developing and rely on balanced hormone signals to ensure proper development. Minor disruptions in these hormone signals caused by endocrine-disrupting chemicals (EDCs) can significantly alter how these body parts and metabolic systems develop. These changes can last a lifetime and may also be passed on to future generations [4,5].

A meta-study by the United Nations World Health Organization (WHO) and the United Nations Environmental Program (UNEP), written by over 60 recognized international experts who worked throughout 2012 to contribute to the meta-analysis to ensure it was an up-to-date compilation of the current scientific knowledge on EDCs, including pesticides, found that:

“…we now know that there are particularly vulnerable periods during fetal and postnatal life when EDCs alone, or in mixtures, have strong and often irreversible effects on developing organs, whereas exposure of adults causes lesser or no effects. Consequently, there is now a growing probability that maternal, fetal and childhood exposure to chemical pollutants play a larger role in the etiology of many endocrine diseases and disorders of the thyroid, immune, digestive, cardiovascular, reproductive and metabolic systems (including childhood obesity and diabetes) than previously thought possible.”[5]

The fetus is most vulnerable during the times when genes are turned on to develop specific organs. Small amounts of hormones give the signals to genes to start developing various body parts and systems such as the reproductive tract, the nervous system, the brain, immune system, hormone systems, and limbs. Small disruptions in these hormone signals can significantly alter the way these body parts and systems will develop, and these altered effects will last a lifetime.

This does not diminish the importance of EDCs in adults, but highlights their significant effects on the fetus and newborn, where hormones can cause lasting impacts by triggering early developmental processes like cell proliferation or differentiation. Research indicates that hormones during embryonic development can lead to the formation of certain structures (e.g., male reproductive tract) or the reduction of others (e.g., specific sex-related brain regions). When normal hormone activity is disrupted by other chemicals acting as hormones during these critical developmental stages, the effects can last a lifetime [16].

Thalidomide is an example of this, as many children were born with underdeveloped limbs and other organs.

The actions of EDCs on fetal development of endocrine and physiological systems are considered programming events. They influence how these systems will function in adults. The WHO and UNEP study found that up to 40% of young men in some countries have low semen quality, along with an increase in genital malformations in baby boys, such as undescended testes and penile deformities. There is a rise in adverse pregnancy outcomes like preterm birth and low birth weight. Additionally, there is an increase in neurobehavioral disorders in children associated with thyroid disruption. The age of breast development in girls is decreasing, which is seen as a risk factor for developing breast cancer later in life. Cancers of the breast, endometrium, ovaries, prostate, testes, and thyroid are also on the rise, along with endometriosis, all linked to the endocrine system [5].

The WHO-UNEP meta-study raised the same issue about the current testing methodologies: “Close to 800 chemicals are known or suspected to be capable of interfering with hormone receptors, hormone synthesis or hormone conversion. However, only a small fraction of these chemicals have been investigated in tests capable of identifying overt endocrine effects in intact organisms.”[5]

The study expresses great concern over the fact that most of the thousands of synthetic chemicals have not been tested at all. The study authors expressed further concerns that the lack of testing means there is no credible scientific data that can validate that the current use of these chemicals is safe. “This lack of data introduces significant uncertainties about the true extent of risks from chemicals that potentially could disrupt the endocrine system.”[5]

The meta-study by Vandenberg et al. stated that there is a need for changes in the methodologies used to test chemicals. Regulators need to take into account the possibility of non-monotonic dose responses when testing for safety rather than just assuming that the toxicity of all chemicals reduces as the dosage is lowered. Neglecting this possibility when testing commercially available chemicals poses serious hazards to human and environmental health. “Thus, fundamental changes in chemical testing and safety determination are needed to protect human health.”[4]

The WHO and UNEP meta-study also emphasized the need to change current methodologies so that tests can be developed for endocrine disruption.

The disturbing fact is that even though regulatory authorities have known about this information for more than thirty years, and even though many (including the U.S. EPA and the EFSA) are duty-bound to protect the public from risky chemicals, only a select few, out of the approximately eight hundred known endocrine disruptors, have been banned or restricted in use.

This issue must be addressed urgently because the public is losing trust in these institutions and their scientific communities. They are putting us, our children, and all other species on our planet in serious danger.

References

  1. Leu, Andre, Poisoning our children, the parent’s guide to the myths of safe pesticides, Acres U.S.A. Greely, Colorado, USA 2018, ISBN 978-1-601-73140-1.
  2. Colborn, Theo, Dianne Dumanoski, and John Peterson Myers. Our Stolen Future: Are We Threatening Our Fertility, Intelligence, and Survival? A Scientific Detective Story. New York: Dutton, 1996.
  3. Cadbury, Deborah. The Feminization of Nature: Our Future at Risk. Middlesex, England: Penguin Books, 1998.
  4. Vandenberg, Laura N., Theo Colborn, Tyrone B. Hayes, Jerrold J. Heindel, David R. Jacobs Jr., Duk-Hee Lee, Toshi Shioda, Ana M. Soto, Frederick S. vom Saal, Wade V. Welshons, R. Thomas Zoeller, and John Peterson Myers. “Hormones and endocrine-disrupting chemicals: Low-dose effects and nonmonotonic dose responses.” Endocrine Reviews 33, no. 3 (June 2012): 378–455. First published ahead of print March 14, 2012, as doi:10.1210/er.2011-1050 (Endocrine Reviews 33: 0000-0000, 2012).
  5. Bergman, Åke, Jerrold J. Heindel, Susan Jobling, Karen A. Kidd, and R. Thomas Zoeller, (eds.) State of the Science of Endocrine Disrupting Chemicals 2012. United Nations Environment Programme and the World Health Organization, 2013.

The Industry Misinformation and Deception on Pesticides, Food Additives, and Chemical Safety Testing

In the previous articles in this series, I showed that the official requirements set by regulatory authorities for specific testing of pesticide-induced diseases in children are nearly non-existent. The OECD guidelines state that “Young healthy adult animals of commonly used laboratory strains should be employed.” The fetus, infant, and pubertal animals (i.e., children) are not tested [1].

The developing fetus, young children, and adolescents going through puberty are three critical stages in human development that are completely overlooked in the guidelines for diseases, endocrine disruption, and cancer. There is no published scientific evidence-based testing demonstrating that any of the current chemicals and pesticides are safe for our children, as there is no requirement to specifically evaluate their safety.

By deliberately avoiding testing, the pesticide cartels and their captive regulators can claim that their studies show no evidence of harm. A classic example is glyphosate. Whenever a study presents evidence of harm, the pesticide cartels and regulators assert that their studies prove it is safe when used as directed. Consequently, they take no action.

A landmark study on glyphosate by Panzacchi et al. was published on June 10, 2025, examining total lifetime exposure to the so-called ‘safe’ levels to which most people are subjected [2].

In this long-term study, the first of its kind, pure glyphosate and two glyphosate-based herbicide formulations were administered to rats through drinking water starting from prenatal life (to the pregnant mothers) at doses of 0.5, 5, and 50 mg/kg body weight per day for a duration of two years. The lower doses in this study are currently considered safe by regulatory authorities.

0.5 mg/kg is four times lower than the US Environmental Protection Agency’s (EPA) proposed ‘safe’ level of 2 mg/kg body weight per day [3].

The study found that the lowest dose of 0.5 mg/kg, along with all the other levels, led to increased rates of both benign and malignant tumors at various anatomic sites compared to the controls. These tumors were found in multiple tissues, including hemolymphoreticular tissues (leukemia), skin, liver, thyroid, nervous system, ovary, mammary gland, adrenal glands, kidney, urinary bladder, bone, endocrine pancreas, uterus, and spleen (hemangiosarcoma).

Increased incidences were observed in both sexes. Most of these involved tumors that are rare in Sprague Dawley rats (background incidence < 1%), with 40% of leukemia deaths in the treated groups occurring early in life. Increased early deaths were also noted for other solid tumors.

“We observed early onset and early mortality for a number of rare malignant cancers, including leukemia, liver, ovary and nervous system tumors. Notably, approximately half of the deaths from leukemia seen in the glyphosate and GBHs treatment groups occurred at less than one year of age, comparable to less than 35-40 years of age in humans. By contrast, no case of leukemia was observed in the first year of age in more than 1600 Sprague Dawley historical controls in carcinogenicity studies conducted by the Ramazzini Institute and the National Toxicology Program (NTP),” stated Dr. Daniele Mandrioli, Director of the Cesare Maltoni Cancer Research Center of the Ramazzini Institute and the Principal Investigator of the study [4].

This study confirms evidence from earlier research, including those by the IARC and Seralini et al., among many others. It also validates the accuracy of “Genetically engineered crops, glyphosate and the deterioration of health in the United States of America,” where Dr. Nancy Swanson, our co-authors, and I demonstrated how glyphosate and GMOs are linked to over 20 chronic diseases in the U.S.

In the chart below, we illustrate the strong correlation between the increase in glyphosate usage and the rise in thyroid cancer. Through standard statistical analysis, we demonstrated a 10,000-to-1 probability linking glyphosate use to the increase in thyroid cancer [5].

The Panzacchi et al. study has detected a greater variety of cancers because it is the first study to include the developing fetus, young children, and adolescents in the total lifetime exposure to small ‘safe’ amounts of glyphosate [2].

This study is among the few where both the treated and control animals were fed organic food. In most trials, animals are given non-organic food, exposing both treated and untreated groups to pesticide residues. This should invalidate any claims that pesticides do not cause harm. How can regulators claim there are no significant differences between the treated animals and the untreated controls when both groups are exposed to pesticides through their food?

This Study Raises Serious Issues about Pesticide Regulation

The results of Panzacchi et al. raise serious issues about why it has taken decades to conduct this type of study to uncover the massive extent of multiple cancers caused by glyphosate.

As an example, the EPA’s fact sheet on glyphosate states: “The EPA conducted a dietary risk assessment for glyphosate based on a worst-case risk scenario, that is, assuming that 100 percent of all possible commodities/acreage were treated, and assuming that tolerance-level residues remained in/on all treated commodities. The Agency concluded that the chronic dietary risk posed by glyphosate food uses is minimal.”

“A reference dose (RfD), or estimate of daily exposure that would not cause adverse effects throughout a lifetime, of 2 mg/kg/day has been proposed for glyphosate, based on the developmental toxicity studies described above.” [3]

So, how did the EPA’s risk assessment studies fail to find leukemia, skin, liver, thyroid, nervous system, ovary, mammary gland, adrenal glands, kidney, urinary bladder, bone, endocrine pancreas, uterus, and spleen cancers, yet conclude that the chronic dietary risk from glyphosate food uses is minimal?

The Deception of Pesticide Testing

The testing of pesticides is intentionally misleading, designed to overlook the vast majority of diseases that occur at their normal rates in people. The testing methodologies can only indicate whether a compound causes health problems; however, they lack the sensitivity to demonstrate safety for significant portions of the human population. A failure to identify adverse health events does not prove safety.

It is crucial to examine these guidelines to understand why.

The Best Practices Testing Guidelines Produce Misinformation

The Organization for Economic Co-operation and Development (OECD) Guidelines for the Testing of Chemicals are regarded as best practices for testing animals for diseases caused by chemicals like pesticides and are comparable to most established good practice testing guidelines.

Guideline 451 of the OECD is used for testing chemicals, such as pesticides, suspected of causing cancer. It requires that “Each dose group and concurrent control group should therefore contain at least 50 animals of each sex.” This group consists of 100 animals, equally divided between males and females. The guidelines also state that “At least three dose levels and a concurrent control should be used” [1].

This means that there must be a control group of 100 animals that are not treated with the chemical. Additionally, there will be three other groups of 100 animals each that receive different dosages of the chemical at the highest, middle, and lowest levels. The number of cancers in each of the treated groups is compared to the number of cancers in the control group. If the cancer rates are the same between the treated and control groups, it is concluded that the cancers were not caused by the chemical. It is assumed that the cancers were due to another factor, since the control group has not been exposed to the chemical and therefore cannot be the cause of the cancers in that group.

The proponents of this methodology argue that the findings indicate a chemical or pesticide does not cause cancer.

However, this method has significant flaws. If one of the treated groups of animals shows one additional case of cancer compared to the control group, it leads to one cancer case for every 100 animals. This represents the lowest theoretical detection rate, indicating that cancer would only be identified if the pesticide caused more than 1,000 cases of cancer per 100,000 people. It would overlook lower cancer rates, which reflect the actual incidence of cancer in our society.

Disease rates are categorized by the number of individuals with the disease per 100,000 people. According to the Centers for Disease Control and Prevention (CDC), in the United States, the rates of common cancers include 57.5 cases of lung cancer per 100,000, 38 cases of colon and rectum cancers per 100,000, 18.4 cases of non-Hodgkin lymphoma per 100,000, 13.2 cases of leukemias per 100,000, 12.8 cases of pancreatic cancer per 100,000, and 8.3 cases of liver and intrahepatic bile duct cancers per 100,000 [6].

Consequently, although no evidence of cancer was found in the dosed groups, the study may overlook a chemical that could cause the most common cancers. According to the CDC, in 2015, the rate of breast cancer was 124.8 per 100,000 women, prostate cancer was 99.1 per 100,000 men, ovarian cancer was 11 per 100,000 women, cervical cancer was 7.6 per 100.000 women, and testicular cancer was 5.6 per 100.000 men [6].

For cancer rates below 1,000 people per 100,000, there is no statistically valid way to determine whether the chemical in question can cause cancer in a group of 100 treated animals that showed no signs of cancer. All cancers currently found in our communities will be ignored. Consequently, they are disregarded in the vast majority of testing. This is why it is scientific fraud to pretend these studies show minimal risk.

The Cover-up of Diseases Other Than Cancer

Guideline 408 of the OECD is for toxicology testing related to diseases. It requires that “at least 20 animals (ten female and ten male) should be used at each dose level.” Similar to cancer guideline 451, guideline 408 states: “At least three dose levels and a concurrent control should be used.”

Under guideline 408, 1 in 20 animals with a disease indicates that the disease could only be detected at a minimum of 5,000 cases per 100,000 people. For sex-specific diseases, such as endometriosis and declines in fertility, the level of disease detection will increase to 10,000 cases per 100,000 people. This means that if the highest dose group finds no evidence of disease, it could easily overlook a chemical that might cause a disease epidemic [1].

Most importantly, the OECD guidelines cannot test for many diseases that affect our communities. For example, the CDC provides the following statistics for some major diseases in the United States: 1,600 people per 100,000 have liver disease, kidney disease affects 2,000 people per 100,000, and stroke impacts 3,000 people per 100,000. The current best practice guidelines overlook these diseases, as they can only detect ailments with a minimum of 5,000 cases per 100,000 people. The only way to achieve this statistically is to use at least 100,000 test animals [7].

Using 100,000 animals would be both costly and impractical. Animal testing raises serious concerns about inhumane cruelty. The reality is that current animal testing guidelines cannot detect diseases at levels that occur in human society, so they should be banned. In today’s world, there is no justification for the inhumane treatment of animals, especially when there are no proven benefits. Numerous other methodologies exist to identify the causes of diseases and ill health. These methods can be combined to consider the totality of evidence and build a strong case for the causes, rather than relying on animal testing [8].

There is No Scientific Proof of Safety for Pesticides, Additives, and Chemicals in our Food

There is no scientific proof supporting the safety of current pesticides, additives, and chemicals in our food, body care products, and household items. Aside from pesticides, most substances go untested, and when testing occurs, it is often designed to deliberately and deceptively ignore the vast majority of diseases as they typically manifest. The testing methodologies can only indicate whether a compound leads to health problems; however, they are not sensitive enough to demonstrate safety for significant portions of the human population. The absence of documented adverse health events does not equate to proof of safety.

References

1. Organisation for Economic Co-operation and Development (OECD) Guidelines for the Testing of Chemicals, Section 4, Health Effects, ISSN: 20745788 (online) https://doi.org/10.1787/20745788, accessed May 12, 2020.

  1. Panzacchi, S., Tibaldi, E., De Angelis, L. et al. Carcinogenic effects of long-term exposure from prenatal life to glyphosate and glyphosate-based herbicides in Sprague–Dawley rats. Environ Health 24, 36 (2025). https://doi.org/10.1186/s12940-025-01187-2
  2. EPA R.E.D. FACTS Glyphosate, https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_PC-417300_1-Sep-93.pdf
  3. Dr. Daniele Mandrioli, International Study Reveals Glyphosate Weed Killers Cause Multiple Types of Cancer, Cesare Maltoni Cancer Research Center, Ramazzini Institute. https://glyphosatestudy.org/news/, June 10, 2025
  1. Nancy L. Swanson, Andre Leu, Jon Abrahamson, and Bradley Wallet, Genetically engineered crops, glyphosate and the deterioration of health in the United States of America, Journal of Organic Systems, 9(2), 2014
  2. U.S. Cancer Statistics Working Group. U.S. Cancer Statistics Data Visualizations Tool, based on November 2017 submission data (1999–2015): U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, and National Cancer Institute; www.cdc.gov/cancer/dataviz, June 2018.
  3. Chronic Disease Data, Centers for Disease Control and Prevention, https://www.cdc.gov/chronicdisease/data/statistics.htm, accessed Oct 31, 2019.
  4. Leu, Andre, Poisoning our children, the parents’ guide to the myths of safe pesticides, Acres U.S.A. Greely, Colorado, USA 2018, ISBN 978-1-601-73140-1.

The Special Needs of Children, the Developing Fetus, and Newborns

Introduction

In last week’s article, I demonstrated how regulatory authorities and the industry are overlooking a significant amount of published research regarding the roles of toxic chemicals, including pesticides, in the substantial increase of Non-Communicable Chronic Diseases (NCDs).

I pointed out that the official requirements from regulatory authorities for specific testing of pesticide-induced diseases in children are nearly nonexistent. Most disturbingly, there is no published scientific evidence-based testing to demonstrate that any of the current chemicals and pesticides are safe for our children, as there is no obligation to specifically test for them.

The article clearly demonstrated how scientists identified the cause by which glyphosate affects nerve development and noted that it cannot be reversed. The primary concern is that the brain is the largest collection of nerves in the human body and continues to develop in unborn, newborn, and growing children. Exposure to small amounts of glyphosate in food can negatively impact the brain’s normal development, leading to a range of significant issues observed in children, including autism spectrum disorder, bipolar disorder, ADHD, and other developmental and behavioral challenges.

The Special Needs of Children, the Developing Fetus, and Newborns

Many scientific researchers have voiced concerns that the current methods for testing pesticides and toxins (including vaccines) are severely inadequate for children. The U.S. President’s Cancer Panel (USPCP) report, written by prominent scientists and medical specialists from the U.S. Department of Health and Human Services, the National Institutes of Health, and the National Cancer Institute, stated, “They (children) are at special risk due to their smaller body mass and rapid physical development, both of which magnify their vulnerability to known or suspected carcinogens, including radiation.” [1]

This is a critical issue because a significant body of published research shows that both the fetus and the newborn are continually exposed to various chemicals, including pesticides, plasticizers, heavy metals like mercury, neurotoxins such as aluminum and fluoride, and endocrine disruptors.

The USPCP stated, ‘Some of these chemicals are found in maternal blood, placental tissue, and breast milk samples from pregnant women and mothers who recently gave birth. These findings indicate that chemical contaminants are being passed on to the next generation, both prenatally and during breastfeeding. Numerous environmental contaminants can cross the placental barrier; to a disturbing extent, babies are born ‘pre-polluted.’ Children also can be harmed by genetic or other damage resulting from environmental exposures sustained by the mother (and in some cases, the father). There is a critical lack of knowledge and appreciation of environmental threats to children’s health and a severe shortage of researchers and clinicians trained in children’s environmental health [1].

Several studies indicate a connection between chemical exposure, especially to pesticides, and the rise of cancer in children. The USPCP report states, “Cancer incidence in U.S. children under 20 years of age has increased” [1].

The information from USCP clearly demonstrates that current regulatory systems have failed to protect unborn and developing children from exposure to numerous toxic pesticides and other chemicals. This failure carries serious implications, particularly regarding the rise of various significant health issues in children and later as adults.

Developmental Neurotoxicity

Scientific research demonstrates that numerous pesticides impact the normal development of the nervous system in fetuses and children. Many pesticides, including organophosphates, carbamates, pyrethroids, and neonicotinoids, cause significant harm because they are specifically designed to target nervous systems. This phenomenon is referred to as a neurotoxin—or in plain English—a nerve poison.

The brain is the most extensive collection of nerve cells, and numerous scientific studies demonstrate that when a fetus and newborn are exposed to small amounts of these pesticides—below the current ‘safe’ limits established by regulatory authorities—they can significantly alter brain function. [2]

One of the most concerning and saddest studies by Guillette et al. evaluated two groups of preschool children in Sonora, Mexico. One group lived in a farming community where pesticides were used, while the other group resided in the foothills, away from pesticide exposure. The image above shows that the group exposed to pesticides exhibits significant brain damage, as indicated by their inability to accurately draw a human figure typical for their age [3].

Researchers at Duke University Medical Center found that developing fetuses and newborns are particularly vulnerable to pesticide levels lower than those currently permitted by regulatory authorities worldwide. Their studies indicated that fetuses and newborns have lower concentrations of protective serum proteins than adults [4].

A major consequence is developmental neurotoxicity, where the poison damages the developing nervous system. This damage disrupts the normal development of the brain and other parts of the nervous system, such as the auditory nerves, optic nerves, and autonomic nervous system, leading to lower IQs, ADHD, autism spectrum disorders, lack of physical coordination, temper loss—anger management issues, bipolar/schizophrenia spectrum disorders, and depression, as well as problems with eyesight and hearing.

Brain Abnormalities and IQ Reductions in Children

Studies conducted independently by researchers at Columbia University’s Center for Children’s Environmental Health, the University of California, Berkeley, and the Mount Sinai School of Medicine found that fetal exposure to small amounts of organophosphate pesticides caused a range of brain abnormalities, leading to children with reduced IQs, diminished attention spans, and increased vulnerability to ADHD [5,6].

Parents should be greatly concerned that one study found no evidence of a lower-limit threshold of exposure to organophosphates in the observed adverse impact on intelligence. This means that even very low levels of exposure could result in reductions in a child’s intelligence.

The study by Rauh et al. published in the journal Proceedings of the National Academy of Sciences of the United States of America has confirmed the findings of previous studies. The researchers used MRI scans that revealed a wide range of visible brain abnormalities in children who were exposed to chlorpyrifos (CPF) in utero through standard, nonoccupational means [7].

The brain damage depicted in the image above was caused by mothers consuming fresh fruits, vegetables, and cereals typically found in the North American diet, which contains regulated ‘safe’ pesticide residues like chlorpyrifos. This proves that exposure to chemicals at levels significantly below the current allowable residues in food can negatively affect a fetus and breastfeeding children, even if the mother does not show any adverse effects from the exposure.

Pesticide and Chemical Residues in Food are not Safe

Eating food with pesticide and chemical residues can be harmful to young children, as their nervous systems are still developing.

Some of the most concerning studies indicate that pesticide damage can be passed on to future generations. Not only are offspring born with damage to the nervous system, reproductive system, and other organs, but great-grandchildren can also be affected as well [8–10].

Researchers in a 2012 study found that pregnant rats and mice exposed to the fungicide vinclozolin during the development of reproductive organs in the fetus experienced significant increases in spermatogenic cell defects, testicular abnormalities, prostate abnormalities, kidney abnormalities, and polycystic ovarian disease in future generations [9].

Another study showed that when pregnant rats were exposed to a combination of permethrin, a common insecticide, and DEET (N,N-diethyl-meta-toluamide), the most common insect repellent, there was an increase in pubertal abnormalities, testis disease, and ovarian disease (primordial follicle loss and polycystic ovarian disease) in future generations [10].

The critical issue with the above studies is that small exposures to pesticides and toxic chemicals (such as adjuvants and preservatives in vaccines) during crucial periods of fetal development can lead to various diseases that may be passed on to future generations. This means that pregnant women consuming food containing trace amounts of pesticides and biologically active chemicals (such as food dyes, preservatives, and other synthetic food additives) may inadvertently expose their children, grandchildren, and great-grandchildren to irreversible damage to their reproductive systems and other organs.

What kind of brutal society poisons its children rather than giving them the best start in life? Exposure to pesticides and neurotoxins should be regarded as some of the worst forms of child abuse.

Parents can prevent this damage by providing their children with a whole food organic diet and avoiding exposure to synthetic toxins. Numerous studies demonstrate the many benefits of an organic diet, particularly in reducing pesticide exposure in children’s bodies. The final article in this series will discuss this in detail and explain why organic foods offer the best value for our health and that of our children [11].

References

  1. “U.S. President’s Cancer Panel 2008–2009 Annual Report; Reducing Environmental Cancer Risk: What We Can Do Now.” Suzanne H. Reuben for the President’s Cancer Panel, U.S. Department Of Health And Human Services, National Institutes of Health, National Cancer Institute, April 2010.
  2. Qiao, Dan, Frederic Seidler, and Theodore Slotkin. “Developmental neurotoxicity of chlorpyrifos modeled in vitro: Comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells.” Environmental Health Perspectives 109, no. 9 (September 2001): 909–913.
  3. E. A. Guillette et al, “An Anthropological Approach to the Evaluation of Preschool Children Exposed to Pesticides in Mexico,” Environmental Health Perspectives, 106(6):347-53, June 1998.
  4. Rauh, Virginia, Srikesh Arunajadai, Megan Horton, Frederica Perera, Lori Hoepner, Dana B. Barr, and Robin Whyatt. “7-year neurodevelopmental scores and prenatal exposure to chlorpyrifos, a common agricultural insecticide.” Environmental Health Perspectives, 119 (2011): 1196–1201. Published online April 21, 2011.
  5. Pastor, Patricia N. and Cynthia A. Reuben, “Diagnosed attention deficit hyperactivity disorder and learning disability: United States, 2004–2006.” National Center for Health Statistics, Vital and Health Statistics, 10, no. 237 (July 2008): 1–14.
  6. Engel, Stephanie M., James Wetmur, Jia Chen, Chenbo Zhu, Dana Boyd Barr, Richard L. Canfield, and Mary S. Wolff. “Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in children.” Environmental Health Perspectives 119 (2011): 1182–1188. Published online April 21, 2011, http://ehp.niehs.nih.gov/1003183/.
  7. Rauh, Virginia, Frederica P. Perera, Megan K. Horton, Robin M. Whyatt, Ravi Bansal, Xuejun Hao, Jun Liu, Dana Boyd Barr, Theodore A. Slotkin, and Bradley S. Peterson. “Brain anomalies in children exposed prenatally to a common organophosphate pesticide.” Proceedings of the National Academy of Sciences of the United States of America 109, no. 20 (May 2012): 7871–7876.
  8. Manikkam, Mohan, Carlos Guerrero-Bosagna, Rebecca Tracey, Md. M. Haque, and Michael K. Skinner. “Transgenerational actions of environmental compounds on reproductive disease and identification of epigenetic biomarkers of ancestral exposures.” PLoS ONE 7, no. 2 (February 2012): e31901.
  9. Manikkam, Mohan, Rebecca Tracey, Carlos Guerrero-Bosagna, and Michael K. Skinner. “Pesticide and insect repellent mixture permethrin and DEET induces epigenetic transgenerational inheritance of disease and sperm epimutations.” Journal of Reproductive Toxicology 34, no. 4 (December 2012): 708–719.
  10. Guerrero-Bosagna, Carlos, Trevor R. Covert, Matthew Settles, Matthew D. Anway, and Michael K. Skinner. “Epigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers.” Reproductive Toxicology 34, no. 4 (December 2012): 694–707.
  11. Leu, Andre. Poisoning Our Children: The Parents’ Guide to the Myths of Safe Pesticides. Acres U.S.A. Greely, Colorado, USA 2018, ISBN 978-1-601-73140-1.

Serious Deficiencies in the Regulation of Toxic Chemicals

Introduction

According to the World Health Organization (WHO), there is a global epidemic of noncommunicable chronic diseases (NCDs), which include heart disease, stroke, cancer, chronic respiratory diseases, and diabetes. WHO states that NCDs are the leading cause of mortality worldwide. “This invisible epidemic is an under-appreciated cause of poverty and hinders the economic development of many countries. The burden is growing — the number of people, families and communities afflicted is increasing” [1].

You cannot contract these diseases from others. Sitting next to individuals with these conditions will not cause you to develop cancer, heart disease, or diabetes. The primary causes are environmental factors and lifestyle choices.

This means we can prevent them by altering our habits, food choices, and farming practices; reducing industrial pollution; and avoiding environmental exposures and lifestyle factors that contribute to them.

Pesticides and chemicals are strongly implicated in this global epidemic; however, researchers and health professionals largely overlook the extent of their role.

Serious Deficiencies in the Regulation of Toxic Chemicals

There are numerous serious deficiencies in the regulation of toxic chemicals used in our food supply, and much of the criteria supporting the current usage patterns relies on outdated assumptions instead of the latest published science [2].

The scientific credibility of pesticide regulatory authorities must be seriously questioned when they approve pesticides based on assumptions lacking data.

A good example of this is the approval of formulated pesticide products as safe based solely on testing one of the ingredients without evaluating the entire formulation. Since the other chemical ingredients are active and added to enhance the effectiveness of the primary ingredient, the assumption that they are inert and will not increase the overall toxicity of the formulation lacks scientific credibility. Limited scientific testing of formulated pesticide products indicates that they can be hundreds of times more toxic to humans than the pure, single active ingredient. There are no requirements to test the toxicity of the entire formulation to establish its safety in preventing NCDs such as heart disease, stroke, cancer, chronic respiratory diseases, and diabetes. There is no requirement to produce credible, evidence-based scientific data [2] to demonstrate that formulated pesticide residues in our food are safe.

The study by Professor Gilles-Eric Seralini et al.  (image above) found that small amounts of GMO maize and Roundup, at daily levels to which most people are exposed over a lifetime, damaged kidneys and livers and caused tumors. This study is the only credible, peer-reviewed, published research conducted by a highly reputable team of independent scientists examining lifetime exposure to realistically small amounts of a formulated pesticide (Roundup). [3] The few other studies are invalid as they were conducted by researchers with financial and other conflicts of interest with pesticide corporations.

The Lack of Testing Chemical Cocktails and their Byproducts

Regulatory authorities approve various pesticides for crops—such as herbicides, fungicides, and insecticides—based on the premise that all can be used in normal crop production. Consequently, multiple residues are found in crops; residue testing revealed that 47.4% of food in the United States contained two or more pesticide residues. The current approval process, which tests each pesticide separately, relies on the assumption that if each chemical is safe on its own, then combinations of these chemicals are also safe. Numerous published scientific studies indicate that combinations of pesticide residues can lead to serious adverse health outcomes due to additive or synergistic effects. The failure to test combinations of approved pesticides for potential health risks means that regulatory authorities lack evidence-based data showing that these residue combinations are safe [2].

The absence of testing for the metabolites generated as pesticides break down represents another significant data gap, particularly given that limited research indicates many of these metabolites are more toxic and longer-lasting than the pesticides themselves. Later in this article, I provide the example of aminomethylphosphonic acid (AMPA), one of the breakdown products of glyphosate, and its contribution to adverse neurodevelopmental outcomes in children, with effects becoming more pronounced at 24 months.

Research shows that breakdown products of neurotoxic pesticides, like neonicotinoids and organophosphates, are significantly more toxic and persistent than their parent chemicals. This should dispel the dangerous and irresponsible myth that modern pesticides break down quickly and become harmless. The reality is that the residues on our food become more toxic over time.

The consideration of the acceptable daily intake (ADI) provides another example. Numerous studies show that over 600 chemicals can act as endocrine disruptors and are more toxic at lower doses. Therefore, establishing the ADI by extrapolating results from higher dose testing involves an assumption that lacks supporting data. The only way to ensure the ADI is safe and does not act as an endocrine disruptor is to conduct tests at the actual residue levels defined for the ADI. This has never been done by the US EPA or the EFSA, despite being a legal requirement since the early 1990s—over 30 years ago.

The special requirements of the fetus, newborn, and growing child concerning developmental neurotoxicity also rely on data-free assumptions. Currently, the pesticide testing involved in the regulatory approval processes does not specifically assess any risks unique to these age groups, and the ADIs are established based on the testing of adolescent animals.

Until testing is specifically designed to evaluate the risks to developing fetuses and young children, there is no evidence-based data applicable to this age group. The fact is, there is not one independent peer-reviewed scientific paper showing that any pesticide is safe for children.

It is the same with intergenerational effects. Unless testing is conducted over several generations, particularly on organs and physiological processes, there is no data to demonstrate that the current ADIs will not result in health problems for future generations. Many scientific studies indicate that exposure to pesticide residues causes adverse health issues in subsequent generations, so neglecting this matter could prove dangerous.

The regulation of pesticides should rely on data obtained from credible scientific studies and testing, rather than on unfounded assumptions, as is currently the case. Additional testing needs to be done for

  • Mixtures and cocktails of chemicals
  • The actual formulated products, not just the active ingredients
  • The toxicity of pesticide metabolites
  • The special requirements of fetuses, newborns, and growing children
  • Endocrine disruption
  • Metabolic disruption
  • Intergenerational effects on all organs and physiological systems
  • Developmental neurotoxicity.

Until this is completed, regulatory bodies lack credible scientific evidence to support the claim that any level of pesticide residue is safe for humans or the environment.

No Published Evidence of Pesticide Safety in Children

The official requirements set by regulatory authorities for specific testing of pesticide-induced diseases in children are nearly non-existent. The OECD guidelines state that “Young healthy adult animals of commonly used laboratory strains should be employed.” The fetus, infant, and pubertal animals (i.e., children) are not tested [4].

This indicates that there will be no data on the safety of pesticides and other chemicals for children in the experiments that utilize these OECD and similar guidelines, which represent the majority of tests.

The developing fetus, young children, and adolescents undergoing puberty are three critical stages in human development that are completely overlooked in the guidelines for diseases, endocrine disruption, and cancer. There is no published scientific evidence-based testing showing that any of the current chemicals and pesticides are safe for our children, as there is no requirement to specifically evaluate their safety.

The current best practice testing guidelines will fail to detect whether chemicals are causing this massive epidemic in our children. Conversely, there is a substantial body of published, peer-reviewed scientific research demonstrating that exposure to minute levels of chemicals and pesticides in unborn and growing children is linked to

  • Autism spectrum disorders
  • Lower IQs
  • Attention deficit hyperactivity disorder (ADHD)
  • Cancers
  • Thyroid disorders
  • Endocrine disruption
  • Immune system problems
  • Lack of physical coordination
  • Loss of temper—anger management issues
  • Bipolar/schizophrenia spectrum of illnesses
  • Depression
  • Digestive system problems
  • Cardiovascular disease
  • Reproductive problems (as adults)
  • Deformities of the genital-urinary systems
  • Changes to metabolic systems, including childhood obesity and diabetes [2].

A good example is the autism epidemic in the developed world. According to the U.S. CDC, in 2000, 670 children per 100,000, or 1 child in 150, had autism. By 2014, the rates of autism rose to 1,680 children per 100,000, or 1 child in 59. This reflects a startling 250% increase over 14 years [5].

The most recent data from the CDC’s Autism and Developmental Disabilities Monitoring Network, published in 2025, estimates that 1 in 31 children aged 8 years in the United States were identified with autism in 2022. This marks an increase from 1 in 36 in 2020. For boys, the rate is significantly higher at 1 in 20, while for girls, it’s approximately 1 in 93. About 26.7% of children with autism have profound autism and require constant long-term care. [6]

It is criminal neglect that has permitted this epidemic to expand to the point where it affects such a high percentage of children. Until recently, it was ignored or denied, and the rise in rates was primarily attributed to increased awareness, screening, diagnostic practices, and genetic factors.

The causes of the epidemic were overlooked despite strong scientific studies showing significant links to the rise in neurotoxins, such as glyphosate from GMO foods, and mercury and aluminum due to the rapid increase in the number of childhood vaccines.

Dr. Nancy Swanson, my co-authors Jon Abrahamson and Bradley Wallet, and I published a peer-reviewed paper, “Genetically engineered crops, glyphosate and the deterioration of health in the United States of America,” demonstrating how glyphosate and GMOs are linked to over 20 chronic diseases in the U.S.

In the chart above, we illustrate the strong correlation between the increase in glyphosate usage and the rise in autism among children. Through a standard statistical analysis, we demonstrated a 10,000 to 1 probability linking the increase in glyphosate use to the rise in autism. [7] When analyzing side effects from a medication, this level of probability of harm is deemed sufficient evidence to withdraw it.

The image above, from Coullery et al., illustrates how glyphosate damages nerve development. The glyphosate-exposed cells exhibited shorter, unbranched axons (the long extended ‘arms’ of the nerve) and less complex dendritic arbors (the smaller ‘fingers’ coming out of the body of the cell). It is evident from the image that the cells exposed to glyphosate do not develop properly and, therefore, cannot function effectively. [8]

The study reveals that gestational exposure to glyphosate leads to neurobehavioral impairments in rat offspring, characterized by motor and cognitive deficits. The scientists identified the mechanism by which glyphosate affects nerve development, specifically by inhibiting the Wnt5a-CaMKII pathway, stating that this effect cannot be reversed. This indicates that the nervous system is a primary target for glyphosate toxicity, raising serious concerns about its effects during critical developmental periods.

The study “Gestational glyphosate exposure and early childhood neurodevelopment in a Puerto Rico birth cohort” by Jenkins et al. examined the relationship between prenatal exposure to glyphosate and its metabolite, aminomethylphosphonic acid (AMPA), and early childhood neurodevelopment. It found that prenatal AMPA concentrations were significantly associated with reduced communication scores at 12 months. At 24 months, AMPA was linked to declines across multiple domains. The study concluded that gestational glyphosate exposure, particularly through AMPA, is associated with adverse neurodevelopmental outcomes, with effects becoming more pronounced at 24 months.[9]

The critical issue is that AMPA results from the degradation of glyphosate and is more persistent and toxic in the environment and in human bodies. Therefore, the argument that glyphosate breaks down rapidly and is harmless is a dangerous myth. In fact, it becomes more harmful and persistent as it breaks down! This is why its widespread use in food production, gardening, roadsides, sidewalks, parks, schools, and playgrounds is dangerously irresponsible.

The primary concern is that the brain is the largest collection of nerves in the human body and continues to develop in unborn, newborn, and growing children. Exposure to small amounts of glyphosate and AMPA in food can adversely affect the brain’s normal development, leading to a range of serious issues observed in children, including autism spectrum disorder, bipolar disorder, ADHD, and other developmental and behavioral challenges.

Adult brains continually regenerate brain cells. These nerve cells are also negatively impacted by glyphosate. The graph below is from our paper “Genetically engineered crops, glyphosate and the deterioration of health in the United States of America.” It illustrates a strong correlation, 10,000 to 1, between the rise in glyphosate usage in GMO crops and deaths from dementia.

The widespread use of glyphosate and other pesticides results in nearly everyone having pesticide residues in their blood and urine. Most individuals are not farmers, and the majority of their exposure comes from food residues. This is why consuming regenerative organic food is essential for our health, especially the health of our children and the overall environment.

References

  1. World Health Organization, The Global Health Observatory, Noncommunicable Diseases https://www.who.int/data/gho/data/themes/noncommunicable-diseases/GHO/noncommunicable-diseases, accessed May 12, 2020.
  1. Leu, Andre. Poisoning Our Children: The Parents’ Guide to the Myths of Safe Pesticides. Acres U.S.A. Greely, Colorado, USA 2018, ISBN 978-1-601-73140-1.

 

  1. Séralini GE, Clair E, Mesnage R, Gress S, Defarge N, Malatesta M, Hennequin D, and de Vendômois JS, Republished study: Long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize, Environmental Sciences Europe (2014, Vol. 26, Article 14)
  2. Organisation for Economic Co-operation and Development (OECD) Guidelines for the Testing of Chemicals, Section 4, Health Effects, ISSN: 20745788 (online) https://doi.org/10.1787/20745788, accessed May 12, 2020.
  3. Data & Statistics on Autism Spectrum Disorder, Content source: National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, https://www.cdc.gov/ncbddd/autism/data.html, Page last reviewed: September 3, 2019.
  4. Centers for Disease Control and Prevention. Prevalence and Early Identification of Autism Spectrum Disorder Among Children Aged 4 and 8 Years — Autism and Developmental Disabilities Monitoring Network, 16 Sites, United States, 2022. MMWR Surveill Summ 2025;74(No. SS-2):1–22.
  5. Nancy L. Swanson, Andre Leu, Jon Abrahamson, and Bradley Wallet, Genetically engineered crops, glyphosate and the deterioration of health in the United States of America, Journal of Organic Systems, 9(2), 2014
  6. Romina Coullery, Alejandra M. Pacchioni, Silvana B. Rosso, Exposure to glyphosate during pregnancy induces neurobehavioral alterations and downregulation of Wnt5a-CaMKII pathway, Reproductive Toxicology, Volume 96, September 2020, Pages 390–398
  7. Jenkins et al., Gestational glyphosate exposure and early childhood neurodevelopment in a Puerto Rico birth cohort, Environmental Research (2024),